The neuroscience of natural rewards: relevance to addictive drugs

AE Kelley, KC Berridge - Journal of neuroscience, 2002 - Soc Neuroscience
Addictive drugs act on brain reward systems, although the brain evolved to respond not to
drugs but to natural rewards, such as food and sex. Appropriate responses to natural rewards …

The amygdalostriatal projection in the rat—an anatomical study by anterograde and retrograde tracing methods

AE Kelley, VB Domesick, WJH Nauta - Neuroscience, 1982 - Elsevier
Tritiated leucine and proline injected into the amygdaloid complex was found to label a
voluminous amygdalostriatal fiber system which is distributed to all parts of the striatum except an …

[HTML][HTML] Memory and addiction: shared neural circuitry and molecular mechanisms

AE Kelley - Neuron, 2004 - cell.com
An important conceptual advance in the past decade has been the understanding that the
process of drug addiction shares striking commonalities with neural plasticity associated with …

Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning

AE Kelley - Neuroscience & biobehavioral reviews, 2004 - Elsevier
The nucleus accumbens is a brain region that participates in the control of behaviors related
to natural reinforcers, such as ingestion, sexual behavior, incentive and instrumental …

Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward

AE Kelley, BA Baldo, WE Pratt, MJ Will - Physiology & behavior, 2005 - Elsevier
Work over the past decade has supported the idea that discrete aspects of appetitive motivation
are differentially mediated by separate but interacting neurochemical systems within the …

The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: An anterograde and retrograde-horseradish peroxidase study

AE Kelley, VB Domesick - Neuroscience, 1982 - Elsevier
We have investigated the distribution and organization of the projection from the hippocampal
formation to the nucleus accumbens in the rat. In the first experiments, horseradish …

Opioid modulation of taste hedonics within the ventral striatum

AE Kelley, VP Bakshi, SN Haber, TL Steininger… - Physiology & …, 2002 - Elsevier
There is a long-standing interest in the role of endogenous opioid peptides in feeding behavior
and, in particular, in the modulation of food reward and palatability. Since drugs such as …

Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function

…, ME Andrzejewski, AFT Arnsten, AE Kelley… - Biological …, 2006 - Elsevier
BACKGROUND: Low doses of psychostimulants, such as methylphenidate (MPH), are widely
used in the treatment of attention-deficit/hyperactivity disorder (ADHD). Surprisingly little is …

Risk taking and novelty seeking in adolescence: introduction to part I

AE Kelley, T Schochet… - Annals of the New York …, 2004 - Wiley Online Library
Risk taking and novelty seeking are hallmarks of typical adolescent behavior. Adolescents
seek new experiences and higher levels of rewarding stimulation, and often engage in risky …

Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus

…, CJ Swanson, AE Kelley - Journal of …, 1995 - Soc Neuroscience
The nucleus accumbens in a brain region considered to be important in the regulation of
appetitive behavior and reinforcement. The accumbens receives afferent input from …