Advanced cirrhosis is associated with generalized vasodilation of unknown origin, which
contributes to mortality. Cirrhotic patients are endotoxemic, and activation of vascular …

Cannabinoid CB1 receptor mRNA was detected using reverse transcription-polymerase
chain reaction (RT-PCR) in endothelial cells from human aorta and hepatic artery and in the …

… Similarly, Khanolkar et al. observed increased CB2 selectivity in the case of … 125 I-Labeled
AM869 was prepared via an S N 2 displacement of its tosylate with Na 125 I (Khanolkar et al., …

Several analogues of the endogenous cannabinoid receptor ligand arachidonylethanolamide
(anandamide) were synthesized and evaluated in order to study (a) the structural …

Activation of cannabinoid CB 2 receptors suppresses neuropathic pain induced by traumatic
nerve injury. The present studies were conducted to evaluate the efficacy of cannabinoid …

Several analogs of an endogenous cannabimimetic, arachidonylethanolamide (anandamide),
were synthesized to study the structural requirements of the ethanolamide head group. …

Identification of arachidonylethanolamide (anandamide) as an endogenous cannabinoid is
one of the most important developments in cannabinoid research in recent years. In a …

The CB1 cannabinoid receptor has been shown to play important physiological roles in the
central nervous system, as well as peripherally, and is a target for development of …

The identification of the CB2 cannabinoid receptor has provided a novel target for the
development of therapeutically useful cannabinergic molecules. We have synthesized benzo[c]…

Anandamide amidohydrolase (AAH) catalyzes the hydrolysis of arachidonylethanolamide (anandamide),
an endogenous cannabinoid receptor ligand. To delineate the structural …