P-glycoprotein-implications of metabolism of neoplastic cells and cancer therapy

A Breier, M Barancík, Z Sulová… - Current cancer drug …, 2005 - ingentaconnect.com
Multidrug resistance (MDR) of neoplastic tissues is a major obstacle in cancer chemotherapy.
The predominant cause of MDR is the overexpression and drug transport activity of P-…

Different mechanisms of drug resistance to hypomethylating agents in the treatment of myelodysplastic syndromes and acute myeloid leukemia

K Šimoničová, Ľ Janotka, H Kavcová, Z Sulová… - Drug Resistance …, 2022 - Elsevier
Resistance to the hypomethylating agents (HMAs) 5-azacytidine (AZA) and 5-aza-2′-deoxycytidine
(DAC) represents a major obstacle in the treatment of elderly patients with …

New insight into p-glycoprotein as a drug target

…, M Seres, M Barancik, Z Sulova - Anti-Cancer Agents in …, 2013 - ingentaconnect.com
Multidrug resistance (MDR) of cancer tissue is a phenomenon in which cancer cells exhibit
reduced sensitivity to a large group of unrelated drugs with different mechanisms of …

LY294, 002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance

M Barančík, V Boháčová, J Sedlák, Z Sulová… - European journal of …, 2006 - Elsevier
The transmembrane transport pump P-glycoprotein (P-gp) causes the efflux of chemotherapeutic
agents from cells and is an important system that secures multidrug resistance (MDR) …

A colorimetric assay for xyloglucan-endotransglycosylase from germinating seeds

Z Sulova, M Lednicka, V Farkas - Analytical Biochemistry, 1995 - Elsevier
One of the key enzymes involved in the breakdown of reserve xyloglucan in seeds of some
dicotyledonous plants during germination is the specific endo-β-(1,4)-glucanase. The …

P-glycoprotein depresses cisplatin sensitivity in L1210 cells by inhibiting cisplatin-induced caspase-3 activation

…, B Uhrík, J Pastorek, J Sedlák, A Breier, Z Sulová - Toxicology in Vitro, 2012 - Elsevier
Multidrug resistance (MDR) is a phenomenon in which cells become resistant to cytostatic
drugs and other substances with diverse chemical structures and cytotoxicity mechanisms. …

[HTML][HTML] Interplay between P-glycoprotein expression and resistance to endoplasmic reticulum stressors

…, L Tomášová, M Šereš, L Pavlíková, A Breier, Z Sulová - Molecules, 2018 - mdpi.com
… Milan Hano prepared the manuscript draft; Milan Hano, Lenka Tomášová, Mário Šereš and
Lucia Pavlíková prepared the literary research; Albert Breier and Zdena Sulová prepared the …

[HTML][HTML] The roles of microRNAs in cancer multidrug resistance

L Pavlíková, M Šereš, A Breier, Z Sulová - Cancers, 2022 - mdpi.com
Simple Summary The resistance of neoplastic cells to multiple drugs is a serious problem in
cancer chemotherapy. The molecular causes of multidrug resistance in cancer are largely …

[HTML][HTML] Detection of the mitochondrial membrane potential by the cationic dye JC-1 in L1210 cells with massive overexpression of the plasma membrane ABCB1 drug …

K Elefantova, B Lakatos, J Kubickova, Z Sulova… - International journal of …, 2018 - mdpi.com
JC-1, a cationic fluorescent dye when added to living cells, is known to be localized exclusively
in mitochondria, particularly in good physiological conditions characterized by sufficient …

[PDF][PDF] Does any relationship exist between P-glycoprotein-mediated multidrug resistance and intracellular calcium homeostasis

Z Sulová, M Seres, M Barancik, L Gibalová, B Uhrík… - Gen Physiol …, 2009 - gpb.sav.sk
Multidrug resistance (MDR) of neoplastic tissue represents a real obstacle to the effective
chemotherapy of cancer. Several mechanisms of MDR were identified, from which the over-…