Transient receptor potential ( TRP ) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Human organic anion transporting polypeptide OATP-B (OATP2B1) is a pH-sensitive transporter
expressed in the apical membranes of small intestinal epithelial cells. In this study, we …

Standardized methods for thermal comfort assessment already exist, namely the predicted
mean vote (PMV) and the adaptive comfort model, both valid for groups of people. To identify …

Rheumatoid arthritis (RA) is a multi-factorial disease characterized by chronic inflammation
and destruction of multiple joints. To date, various biologic treatments for RA such as anti-…

Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms
underlying this outcome are unclear. Here, we show that low vitamin D status worsens …

A prototype of a multifunctional, stand-alone Personalized Environmental Control System (PECS)
was developed and evaluated. The prototype comprised an electric heating panel and …

Dysregulation of blood-brain barrier (BBB) transport function is thought to exacerbate
neuronal damage in acute ischemic stroke. The purpose of this study was to clarify the …

Introduction Osteonecrosis of the jaw (ONJ) occurring after invasive dental treatment often
adversely affects patients’ activities of daily living. Long-term administration of strong anti-…

Fragment-based ligand discovery was successfully applied to histone deacetylase HDAC2.
In addition to the anticipated hydroxamic acid- and benzamide-based fragment screening …

Neuropathological lesions found in chronic human Minamata disease tend to be localized in
the calcarine cortex of occipital lobes, the pre- and postcentral lobuli, and the temporal gyri. …