Through functional expression screening, we identified a gene, designated Humanin (HN)
cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by …

Arginine has been used to suppress protein aggregation and protein–protein or protein–surface
interactions during protein refolding and purification. While its biotechnology …

In this review we offer an explanation for the means by which cryoprotectants stabilize proteins
during freezing and destabilize them at physiological temperatures. Dimethylsulfoxide, …

A variety of excipients are used to stabilize proteins, suppress protein aggregation, reduce
surface adsorption, or to simply provide physiological osmolality. The stabilizers encompass a …

It has been found that W/O/W-type multiple-phase emulsions can be prepared by a two-step
procedure of emulsification using a variety of nonionic emulsifying agents. The first step in …

Solvent conditions play a major role in a wide range of physical properties of proteins in
solution. Organic solvents, including dimethyl sulfoxide (DMSO), have been used to precipitate, …

Revised Manuscript Received October 11, 1994® abstract: Surface tension measurements
were carried out at 20 C by a capillary drop—weight method on aqueous solutions of sodium …

The stability of proteins is affected by a variety of solvent additives. Sugars, certain amino
acids and salts, and polyhydric alcohols stabilize proteins in solution and during freeze-thawing…

A novel factor, termed Humanin (HN), antagonizes against neurotoxicity by various types of
familial Alzheimer's disease (AD) genes [V642I and K595N/M596L (NL) mutants of amyloid …

Brain atrophy caused by neuronal loss is a prominent pathological feature of Alzheimer's
disease (AD). Amyloid (A ), the major component of senile plaques, is considered to play a …