To elucidate the physiological role of sterol regulatory element-binding protein-1 (SREBP-1),
the hepatic mRNA levels of genes encoding various lipogenic enzymes were estimated in …

In an attempt to identify transcription factors which activate sterol-regulatory element-binding
protein 1c (SREBP-1c) transcription, we screened an expression cDNA library from adipose …

Previous studies have demonstrated that polyunsaturated fatty acids (PUFAs) suppress sterol
regulatory element-binding protein 1c (SREBP-1c) expression and, thus, lipogenesis. In …

Obesity is a common nutritional problem often associated with diabetes, insulin resistance,
and fatty liver (excess fat deposition in liver). Leptin-deficient Lep ob /Lep ob mice develop …

Recent studies on the in vivo roles of the sterol regulatory element binding protein (SREBP)
family indicate that SREBP-2 is more specific to cholesterogenic gene expression whereas …

We use a wideband optical comb source with 10THz bandwidth for 2.15 Pb/s transmission
over 31km of a new, homogeneous 22-core single-mode multi-core fiber using 399 × 25GHz …

Dietary polyunsaturated fatty acids (PUFA) are negative regulators of hepatic lipogenesis
that exert their effects primarily at the level of transcription. Sterol regulatory element-binding …

In the process of seeking sterol regulatory element-binding protein 1a (SREBP-1a) target
genes, we identified and cloned a cDNA clone encoding mouse Δ 5 -desaturase (D5D). The …

Liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs) are
members of nuclear receptors that form obligate heterodimers with retinoid X receptors (RXRs). …

Atherosclerotic coronary heart disease is a common complication of the insulin resistance
syndrome that can occur with or without diabetes mellitus. Thiazolidinediones (TZDs), which …