[HTML][HTML] Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

DI Draganov, JF Teiber, A Speelman, Y Osawa… - Journal of lipid …, 2005 - ASBMB
The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and
PON3. Their physiological role(s) and natural substrates are uncertain. We developed a …

Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent

DA Wink, Y Osawa, JF Darbyshire, CR Jones… - Archives of biochemistry …, 1993 - Elsevier
The effect of nitric oxide (NO) on cytochrome P450-mediated benzyloxyresorufin and
ethoxyresorufin O-dealkylase activity of rat hepatic postmitochondrial (S-9) or microsomal …

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

…, Y Morishima, HM Peng, Y Osawa - … biology and medicine, 2010 - journals.sagepub.com
The Hsp90/Hsp70-based chaperone machinery plays a well-established role in signaling
protein function, trafficking and turnover. A number of recent observations also support the …

Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases

WB Pratt, JE Gestwicki, Y Osawa… - Annual review of …, 2015 - annualreviews.org
Currently available therapies for adult onset neurodegenerative diseases provide symptomatic
relief but do not modify disease progression. Here we explore a new neuroprotective …

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

…, Y Morishima, DE Merry, WB Pratt, Y Osawa… - Nature chemical …, 2013 - nature.com
We sought new strategies to reduce amounts of the polyglutamine androgen receptor (polyQ
AR) and achieve benefits in models of spinobulbar muscular atrophy, a protein aggregation …

Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations

…, A Tamura, H Nakagawa, Y Morishima, Y Osawa… - Pharmaceutical …, 2009 - Springer
Purpose Single nucleotide polymorphisms (SNPs) of the ATP-binding cassette (ABC)
transporter ABCG2 gene have been suggested to be a significant factor in patients’ responses to …

[HTML][HTML] The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts

WB Pratt, Y Morishima, Y Osawa - Journal of Biological Chemistry, 2008 - ASBMB
In the two decades that have elapsed since the molecular chaperone Hsp90 2 was shown to
regulate the function of steroid receptors (1), 200 signaling proteins have been found to be …

Cigarette smoking and erectile dysfunction: focus on NO bioavailability and ROS generation

…, AJ Lee, FRC Giachini, R Leite, Y Osawa… - The journal of sexual …, 2008 - academic.oup.com
Introduction Thirty million men in the United States suffer from erectile dysfunction (ED) and
this number is expected to double by 2025. Considered a major public health problem, …

Role of nitric oxide in NMDA-evoked release of [3H]-dopamine from striatal slices

I Hanbauer, D Wink, Y Osawa, GM Edelman… - …, 1992 - journals.lww.com
ROLE OF NITRIC OXIDE IN NMDA-EVOKED RELEASE OF [3H]-DOPAMINE... : NeuroReport
ROLE OF NITRIC OXIDE IN NMDA-EVOKED RELEASE OF [3H]-DOPAMINE FROM STRIATAL …

CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

…, AM Wang, Z Yu, WB Pratt, Y Osawa… - Human molecular …, 2008 - academic.oup.com
CHIP (carboxy terminus of Hsc70-interacting protein) an E3 ubiquitin ligase that binds to
Hsp70 and Hsp90, promotes degradation of several Hsp90-regulated signaling proteins and …