Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-γ

…, A Matsushima, Y Shimohigashi - Environmental …, 2008 - ehp.niehs.nih.gov
Background Various lines of evidence have shown that bisphenol A [BPA; HO-C 6 H 4 -C(CH
3 ) 2 -C 6 H 4 -OH] acts as an endocrine disruptor when present in very low doses. We …

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

…, X Liu, H Okada, A Matsushima, Y Shimohigashi - Toxicology letters, 2006 - Elsevier
Bisphenol A (BPA) has been acknowledged as an estrogenic chemical able to interact with
human estrogen receptors (ER). Many lines of evidence reveal that BPA has an impact as an …

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

…, S Kawabata, M Kimura, Y Shimohigashi - Journal of …, 2007 - academic.oup.com
Many lines of evidence reveal that bisphenol A (BPA) functions at very low doses as an
endocrine disruptor. The human estrogen-related receptor γ (ERRγ) behaves as a constitutive …

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

…, M Shimohigashi, Y Shimohigashi - Environmental …, 2010 - ehp.niehs.nih.gov
Background Bisphenol AF has been acknowledged to be useful for the production of CF 3 -containing
polymers with improved chemical, thermal, and mechanical properties. Because …

Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes.

…, M Nakai, T Ogawa, Y Shimohigashi… - Proceedings of the …, 1995 - National Acad Sciences
The nucleotide sequences of four genes encoding Trimeresurus gramineus (green habu
snake, crotalinae) venom gland phospholipase A2 (PLA2; phosphatidylcholine 2-acylhydrolase…

Accelerated evolution of crotalinae snake venom gland serine proteases

…, K Nakashima, I Nobuhisa, T Chijiwa, Y Shimohigashi… - FEBS letters, 1996 - Elsevier
Eight cDNAs encoding serine proteases isolated from Trimeresurus flavoviridis (habu snake)
and T. gramineus (green habu snake) venom gland cDNA libraries showed that …

Placenta expressing the greatest quantity of bisphenol A receptor ERRγ among the human reproductive tissues: predominant expression of type-1 ERRγ isoform

…, M Shimohigashi, Y Shimohigashi - Journal of …, 2009 - academic.oup.com
Estrogen-related receptor γ (ERRγ), one of the 48 human nuclear receptors, has a fully
active conformation with no ligand. We recently demonstrated that ERRγ binds strongly …

Binding characteristics of dialkyl phthalates for the estrogen receptor

…, M Noguchi, M Takatsuki, Y Shimohigashi - Biochemical and …, 1999 - Elsevier
Dialkyl phthalates have been suggested to function as xenoestrogen. To explore the structural
essentials, a series of ring and alkyl-chain isomers of dialkyl phthalates C 6 H 4 (COOC n …

Endocrine disrupter bisphenol A increases in situ estrogen production in the mouse urogenital sinus

…, Y Yoshio, A Matsushima, Y Shimohigashi… - Biology of …, 2011 - academic.oup.com
The balance between androgens and estrogens is very important in the development of the
prostate, and even small changes in estrogen levels, including those of estrogen-mimicking …

[HTML][HTML] Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor.

…, M Hagiya, S Shimizu, T Nose, Y Shimohigashi… - Journal of Biological …, 1994 - Elsevier
Hepatocyte growth factor (HGF) has a strong affinity for heparin. About one fourth of HGF
secreted from MRC-5 human embryonic lung fibroblast cells was found to be associated with …