Permeation of the cell membrane leading to cell death is a mechanism used by a large
number of membrane-lytic peptides. Some are linear, mostly helical, and others contain one or …

… Mesentericin Y also uses a receptor that is located only on the specific bacteria listeria.54
Similarly to nisin, removal of the receptor-binding domain in mesentericin resulted in a loss of …

The increasing resistance of bacteria to conventional antibiotics resulted in a strong effort to
develop antimicrobial compounds with new mechanisms of action. Antimicrobial peptides …

… potential from vesicles (Sims et al., 1974; Loew et al., 1983) has been previously described
in studies on the permeating properties of paradaxin and some of its analogues (Shai et al., …

… and Shai Y. (2003) New lytic peptides based on the D, L amphipathic helix motif preferentially
kill tumor cells compared to nornal cells. Biochemistry 42: 9346–9354 39 Shin SY, Kang …

The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic
α-helical peptide isolated from human. LL-37 is considered to play an important role in the …

Studies on lipid−peptide interactions of cytolytic polypeptides tend to emphasize the
importance of the amphipathic α-helical structure for their cytolytic activity. In this study, …

Binding of lipopolysaccharide (LPS) to macrophages results in proinflammatory cytokine
secretion. In extreme cases it leads to endotoxic shock. A few innate immunity antimicrobial …

… Author links open overlay panel Yechiel Shai a 1 , Ziv Oren a … Another example is
mesentericin Y [31]. Further support for a non-receptor mediated function of most antimicrobial …

Host-defense cationic antimicrobial peptides (≈12–50 aa long) play an essential protective
role in the innate immune system of all organisms. Lipopeptides, however, are produced …