User profiles for Y. Jounaidi

youssef jounaidi

Harvard Medical School
Verified email at mgh.harvard.edu
Cited by 1660

Differential assembly diversifies GABAA receptor structures and signalling

…, R Desai, K Naydenova, T Malinauskas, Y Jounaidi… - Nature, 2022 - nature.com
Type A γ-aminobutyric acid receptors (GABA A Rs) are pentameric ligand-gated chloride
channels that mediate fast inhibitory signalling in neural circuits 1 , 2 and can be modulated by …

Conditionally replicating adenoviruses for cancer treatment

Y Jounaidi, JC Doloff… - Current cancer drug targets, 2007 - ingentaconnect.com
Replication-conditional, oncolytic adenoviruses are emerging as powerful tools in the
warfare on cancer. The ability to modify cell-specific infectivity or tissue-specific replication …

[HTML][HTML] Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment

…, M Ventin, G Cattaneo, Y Li, Y Jounaidi… - Nature …, 2023 - nature.com
The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due
to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector …

Cytochrome P450-based cancer gene therapy: recent advances and future prospects

…, L CHEN, JED HECHT, Y JOUNAIDI - Drug metabolism …, 1999 - Taylor & Francis
… reactions, recent studies have shown no significant loss of P450-dependent prodrug activation
in P450-transduced tumor cells grown under hypoxic conditions (Jounaidi and Waxman, …

Cancer chemotherapy and drug metabolism

…, CS Morrow, AJ Townsend, Y Jounaidi… - Drug Metabolism and …, 2005 - ASPET
Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics
and pharmacodynamics of many antineoplastic agents. Metabolism and transport …

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

JM Pascussi, Y Jounaidi, L Drocourt… - Biochemical and …, 1999 - Elsevier
Pregnane X Receptor (PXR) has been recently shown to regulate the inducible expression
of CYP3A genes in response to xenobiotics and steroids. PXR forms a heterodimer with the …

Detection of a CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

Y Jounaıdi, V Hyrailles, L Gervot, P Maurel - Biochemical and biophysical …, 1996 - Elsevier
In liver samples from 19 Caucasian subjects, the CYP3A5 protein was detected in 74% of
individuals (14/19), while the messenger was shown to be expressed in 100% of individuals, …

Induction of CYP1A1 Gene by Benzimidazole Derivatives During Caco‐2 Cell Differentiation: Evidence for an aryl‐Hydrocarbon Receptor‐Mediated Mechanism

…, I Fabre, P Lesca, Y Jounaidi… - European journal of …, 1996 - Wiley Online Library
The Caco‐2 cell line, derived from a human colon adenocarcinoma, is unique in its property
of spontaneously differentiating into a mature enterocyte cell type during its growth in culture…

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics

X Yang, Y Jounaidi, JB Dai, F Marte-Oquendo… - …, 2018 - pubs.asahq.org
… Individual binary results (1 for loss of righting reflexes; 0 otherwise) were tabulated and
analyzed by fitting logistic functions [Y = Max * 10 ^ (nH * log[drug])/(10 ^(nH*log[drug]) + 10^ (nH …

Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy

Y Jounaidi, JED Hecht, DJ Waxman - Cancer research, 1998 - AACR
Cyclophosphamide (CPA) and ifosfamide (IFA) are widely used anticancer prodrugs that
are bioactivated in the liver by specific cytochrome P450 enzymes (CYPs). The therapeutic …