CYCLOOXYGENASES 1 AND 2
JR Vane, YS Bakhle, RM Botting - Annual review of …, 1998 - annualreviews.org
▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key
enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several …
enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several …
Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness
MBH Youdim, YS Bakhle - British journal of pharmacology, 2006 - Wiley Online Library
A few years after the foundation of the British Pharmacological Society, monoamine oxidase
(MAO) was recognized as an enzyme of crucial interest to pharmacologists because it …
(MAO) was recognized as an enzyme of crucial interest to pharmacologists because it …
[HTML][HTML] COX-2 and cancer: a new approach to an old problem
YS Bakhle - British journal of pharmacology, 2001 - ncbi.nlm.nih.gov
Abbreviations: APC, adenomatous polyposis coli; bFGF, basic fibroblast growth factor; COX,
cyclooxygenase; CRC, colorectal cancer; C2I, selective inhibitor of COX-2; EGF, epidermal …
cyclooxygenase; CRC, colorectal cancer; C2I, selective inhibitor of COX-2; EGF, epidermal …
Conversion of angiotensin I to angiotensin II by cell-free extracts of dog lung
YS Bakhle - Nature, 1968 - nature.com
RECENT work 1 has established the crucial part played by the pulmonary circulation in the
pharmacodynamics of the renin-angiotensin system in the dog. It is the only vascular bed that …
pharmacodynamics of the renin-angiotensin system in the dog. It is the only vascular bed that …
Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme
SH Ferreira, LJ Greene, VA Alabaster, YS Bakhle… - Nature, 1970 - nature.com
THE venom from Bothrops jararaca contains enzymes which liberate kinins from plasma
kininogen 1 . Ferreira 2 found that the venom also contained a peptidic fraction (bradykinin …
kininogen 1 . Ferreira 2 found that the venom also contained a peptidic fraction (bradykinin …
Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with …
…, PMR Silva, HL Lenzi, YS Bakhle… - The Journal of …, 2000 - journals.aai.org
In noninfected rats, challenge with allergen following local IgE sensitization induced a pleurisy
marked by intense protein exudation that plateaued from 30 min to 4 h after challenge, …
marked by intense protein exudation that plateaued from 30 min to 4 h after challenge, …
[PDF][PDF] Cyclooxygenase-2 and its regulation in inflammation
YS Bakhle, RM Botting - Mediators of inflammation, 1996 - downloads.hindawi.com
There is no doubt that the identification of an inducible isoform of cyclooxygenase (here
referred to as cyclooxygenase-2 or COX-2) has brought about a renaissance in prostanoid …
referred to as cyclooxygenase-2 or COX-2) has brought about a renaissance in prostanoid …
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain
…, WGP Dos Reis, YS Bakhle… - British Journal of …, 2008 - Wiley Online Library
Background and purpose: The analgesics, paracetamol and dipyrone are weak inhibitors of
the cyclooxygenase isoforms 1 or 2 (COX‐1, COX‐2) but more potent on COX‐3. Both are …
the cyclooxygenase isoforms 1 or 2 (COX‐1, COX‐2) but more potent on COX‐3. Both are …
Selective inhibitors of cyclo‐oxygenase‐2 (COX‐2) induce hypoalgesia in a rat paw model of inflammation
…, DL Ferreira‐Alves, YS Bakhle - British Journal of …, 2002 - Wiley Online Library
It is well‐established that inhibitors of cyclo‐oxygenase (COX) and hence of prostaglandin (PG)
biosynthesis reverse inflammatory hyperalgesia and oedema in both human and animal …
biosynthesis reverse inflammatory hyperalgesia and oedema in both human and animal …
Pharmacokinetic function of the pulmonary circulation.
YS Bakhle, JR Vane - Physiological Reviews, 1974 - journals.physiology.org
Over the past 6 yr there has been increasing interest in the pharmacokinetic role of the
pulmonary circulation-that is to say, the way in which the cells and enzyme systems of the …
pulmonary circulation-that is to say, the way in which the cells and enzyme systems of the …