Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
…, D Zhou, K Qian, T Hricik, J Cote, X Han… - Elife, 2015 - elifesciences.org
10.7554/eLife.07938.001 RBM15, an RNA binding protein, determines cell-fate specification
of many tissues including blood. We demonstrate that RBM15 is methylated by protein …
of many tissues including blood. We demonstrate that RBM15 is methylated by protein …
[HTML][HTML] The genomic sequence of ectromelia virus, the causative agent of mousepox
…, MI Danila, Z Feng, RML Buller, C Wang, X Han… - Virology, 2003 - Elsevier
Ectromelia virus is the causative agent of mousepox, an acute exanthematous disease of
mouse colonies in Europe, Japan, China, and the US The Moscow, Hampstead, and NIH79 …
mouse colonies in Europe, Japan, China, and the US The Moscow, Hampstead, and NIH79 …
Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro
X Han, R Li, W Zhang, X Yang, CG Wheeler… - Journal of Neuro …, 2014 - Springer
Protein arginine methyltransferase 5 (PRMT5) catalyzes the formation of ω-NG,N′G-symmetric
dimethylarginine residues on histones as well as other proteins. These modifications …
dimethylarginine residues on histones as well as other proteins. These modifications …
Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis
M Hu, P Che, X Han, GQ Cai, G Liu, V Antony… - … of Pharmacology and …, 2014 - ASPET
Myofibroblasts are effector cells in fibrotic disorders that synthesize and remodel the
extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in …
extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in …
[HTML][HTML] Enhanced sensitivity of patient-derived pediatric high-grade brain tumor xenografts to oncolytic HSV-1 virotherapy correlates with nectin-1 expression
…, VM Kelly, SL Youngblood, CP Langford, X Han… - Scientific reports, 2018 - nature.com
Pediatric high-grade brain tumors and adult glioblastoma are associated with significant
morbidity and mortality. Oncolytic herpes simplex virus-1 (oHSV) is a promising approach to …
morbidity and mortality. Oncolytic herpes simplex virus-1 (oHSV) is a promising approach to …
[HTML][HTML] The role of Src family kinases in growth and migration of glioma stem cells
X Han, W Zhang, X Yang… - International …, 2014 - spandidos-publications.com
Src family kinases (SFKs) are highly expressed and active in clinical glioblastoma multiforme
(GBM) specimens. SFKs inhibitors have been demonstrated to inhibit proliferation and …
(GBM) specimens. SFKs inhibitors have been demonstrated to inhibit proliferation and …
Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses
…, T Etminan, CP Langford, H Xu, X Han… - Neuro …, 2015 - academic.oup.com
Background Childhood medulloblastoma is associated with significant morbidity and mortality
that is compounded by neurotoxicity for the developing brain caused by current therapies, …
that is compounded by neurotoxicity for the developing brain caused by current therapies, …
A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma
SP Weathers, X Han, DD Liu, CA Conrad… - Journal of neuro …, 2016 - Springer
Antiangiogenic therapy can rapidly reduce vascular permeability and cerebral edema but
high doses of bevacizumab may induce selective pressure to promote resistance. This trial …
high doses of bevacizumab may induce selective pressure to promote resistance. This trial …
[HTML][HTML] Plasma biomarkers of depressive symptoms in older adults
The pathophysiology of negative affect states in older adults is complex, and a host of central
nervous system and peripheral systemic mechanisms may play primary or contributing …
nervous system and peripheral systemic mechanisms may play primary or contributing …
Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin …
The extracellular matrix of the normal adult brain lacks expression of most of the adhesive
glycoproteins that are known to promote cell attachment, and it has been thought that the …
glycoproteins that are known to promote cell attachment, and it has been thought that the …