Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

…, D Zhou, K Qian, T Hricik, J Cote, X Han… - Elife, 2015 - elifesciences.org
10.7554/eLife.07938.001 RBM15, an RNA binding protein, determines cell-fate specification
of many tissues including blood. We demonstrate that RBM15 is methylated by protein …

[HTML][HTML] The genomic sequence of ectromelia virus, the causative agent of mousepox

…, MI Danila, Z Feng, RML Buller, C Wang, X Han… - Virology, 2003 - Elsevier
Ectromelia virus is the causative agent of mousepox, an acute exanthematous disease of
mouse colonies in Europe, Japan, China, and the US The Moscow, Hampstead, and NIH79 …

Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro

X Han, R Li, W Zhang, X Yang, CG Wheeler… - Journal of Neuro …, 2014 - Springer
Protein arginine methyltransferase 5 (PRMT5) catalyzes the formation of ω-NG,N′G-symmetric
dimethylarginine residues on histones as well as other proteins. These modifications …

Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis

M Hu, P Che, X Han, GQ Cai, G Liu, V Antony… - … of Pharmacology and …, 2014 - ASPET
Myofibroblasts are effector cells in fibrotic disorders that synthesize and remodel the
extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in …

[HTML][HTML] Enhanced sensitivity of patient-derived pediatric high-grade brain tumor xenografts to oncolytic HSV-1 virotherapy correlates with nectin-1 expression

…, VM Kelly, SL Youngblood, CP Langford, X Han… - Scientific reports, 2018 - nature.com
Pediatric high-grade brain tumors and adult glioblastoma are associated with significant
morbidity and mortality. Oncolytic herpes simplex virus-1 (oHSV) is a promising approach to …

[HTML][HTML] The role of Src family kinases in growth and migration of glioma stem cells

X Han, W Zhang, X Yang… - International …, 2014 - spandidos-publications.com
Src family kinases (SFKs) are highly expressed and active in clinical glioblastoma multiforme
(GBM) specimens. SFKs inhibitors have been demonstrated to inhibit proliferation and …

Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses

…, T Etminan, CP Langford, H Xu, X Han… - Neuro …, 2015 - academic.oup.com
Background Childhood medulloblastoma is associated with significant morbidity and mortality
that is compounded by neurotoxicity for the developing brain caused by current therapies, …

A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma

SP Weathers, X Han, DD Liu, CA Conrad… - Journal of neuro …, 2016 - Springer
Antiangiogenic therapy can rapidly reduce vascular permeability and cerebral edema but
high doses of bevacizumab may induce selective pressure to promote resistance. This trial …

[HTML][HTML] Plasma biomarkers of depressive symptoms in older adults

…, SX Xie, YY Leung, LS Wang, MA Kling, X Han… - Translational …, 2012 - nature.com
The pathophysiology of negative affect states in older adults is complex, and a host of central
nervous system and peripheral systemic mechanisms may play primary or contributing …

Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin …

…, J Stewart Jr, CW Prince, PL Chang, M Trikha, X Han… - Cancer research, 2002 - AACR
The extracellular matrix of the normal adult brain lacks expression of most of the adhesive
glycoproteins that are known to promote cell attachment, and it has been thought that the …