Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies

…, A Mulder, AP den Hartog, H Zilaout, W Goutier… - Bioorganic & medicinal …, 2010 - Elsevier
The synthesis and structure–activity relationship studies of imidazoles are described. The
target compounds 6–20 represent a novel chemotype of potent and CB 2 /CB 1 selective …

Potent peptidic fusion inhibitors of influenza virus

…, B Stoops, RJ Vreeken, J Vermond, W Goutier… - Science, 2017 - science.org
Influenza therapeutics with new targets and mechanisms of action are urgently needed to
combat potential pandemics, emerging viruses, and constantly mutating strains in circulation. …

A small-molecule fusion inhibitor of influenza virus is orally active in mice

…, S Blokland, D Garg, W Yu, W Goutier… - Science, 2019 - science.org
INTRODUCTION Annual influenza epidemics and episodic pandemics continue to cause
widespread illness and mortality. Strategies to prevent and treat acute influenza infection have …

Nicotine‐induced locomotor sensitization: pharmacological analyses with candidate smoking cessation aids

W Goutier, M Kloeze, AC McCreary - Addiction biology, 2016 - Wiley Online Library
There are a number of approved therapeutics for the management of alcohol dependence,
which might also convey the potential as smoking cessation aids. The present study …

The effect of varenicline on the development and expression of nicotine‐induced behavioral sensitization and cross‐sensitization in rats

W Goutier, MB Kloeze, AC McCreary - Addiction biology, 2015 - Wiley Online Library
The present study focused on the evaluation of behavioral sensitization and cross‐sensitization
induced by nicotine and varenicline in rats. Furthermore, it examined the influence of …

WS-50030 [7-{4-[3-(1H-inden-3-yl) propyl] piperazin-1-yl}-1, 3-benzoxazol-2 (3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with …

…, F Pruthi, M Lai, D Smith, W Goutier… - … of Pharmacology and …, 2010 - ASPET
The preclinical characterization of WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]
is described. In vitro binding and functional studies revealed …

[HTML][HTML] An orally active small molecule fusion inhibitor of influenza virus

…, S Blokland, D Garg, W Wu, W Goutier… - Science (New York …, 2019 - ncbi.nlm.nih.gov
Recent characterization of broadly neutralizing antibodies (bnAbs) against influenza virus
identified the conserved hemagglutinin (HA) stem as a target for development of universal …

Putative changes in dopaminergic neurotransmission following nicotine induced behavioural sensitisation

W Goutier - 2011 - eprints.nuim.ie
Behavioural sensitisation is a progressive enhancement of stereotypic or locomotor
behaviour following repeated intermittent administration of a psychostimulant or stress. It is a …

The role of design for additive manufacturing in the successful economical introduction of AM

THJ Vaneker - Procedia Cirp, 2017 - Elsevier
… The work presented in this paper was to a very large extend based on the master assignments
conducted by Marijn Goutier [1] and to a lesser extend the work of Wouter van der Haar [5]…

[PDF][PDF] Thursday, February 2nd: Parallel Session

JM Masur, W van Atteveldt, K Welbers, D Trilling - research.utwente.nl
5192466: When “sometimes” means “often”: How stereotypes affect the interpretation of
quantitative expressions. Camiel J. Beukeboom, Christian Burgers, Jesper van der Meer …