Morphological changes in mitochondria are observed early in the course of acetaminophen
(AA)-induced hepatotoxicity, and mitochondrial dysfunction has been observed both in vivo …

Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the antidysrhythmic
drug amiodarone (AM). We tested the potential usefulness of pirfenidone against AM…

Dietary 2‐acetylaminofluorene (2‐AAF) coupled with a stimulus for cell proliferation such as
a 2/3 partial hepatectomy (PH) or a necrotizing dose of carbon tetrachloride is frequently …

Bromobenzene (BB) and furosemide (FS) are two hepatotoxicants whose bioactivation to
reactive intermediates is crucial to the development of liver injury. However, the events which …

Acetaminophen‐induced (750 mg per kg po) hepatotoxicity in mice is characterized by
hepatomegaly and massive centrilobular congestion which precede the appearance of necrosis. …

Amiodarone (AM) is an efficacious antidysrhythmic agent that can cause numerous adverse
effects, including potentially life-threatening pulmonary fibrosis. The current study was …

Acetaminophen-induced hypothermia and hepatic congestion, their modification by N-acetylcysteine
(NAC) and their relationship to hepatotoxicity were studied in Swiss white mice. …

Amiodarone (AM) is an antidysrhythmic agent with a propensity to cause pulmonary toxicity,
including potentially fatal fibrosis. In the present study, the potential roles of c-Jun and …

Solid complexes of the type [MeHg (NucH2)] N03,[MeHg (NucH)], and [(MeHg) 2 (NucH)]
N03 (NucH2= guanosine or inosine) have been prepared by the reaction of the nucleosides …

Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM-induced …