Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity
PJ Donnelly, RM Walker, WJ Racz - Archives of toxicology, 1994 - Springer
Morphological changes in mitochondria are observed early in the course of acetaminophen
(AA)-induced hepatotoxicity, and mitochondrial dysfunction has been observed both in vivo …
(AA)-induced hepatotoxicity, and mitochondrial dysfunction has been observed both in vivo …
Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity
JW Card, WJ Racz, JF Brien, SB Margolin… - Toxicological …, 2003 - academic.oup.com
Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the antidysrhythmic
drug amiodarone (AM). We tested the potential usefulness of pirfenidone against AM…
drug amiodarone (AM). We tested the potential usefulness of pirfenidone against AM…
Alternative methods of selecting rat hepatocellular noduli resistant to 2‐acetylaminofluorene
…, D Armstrong, RA Becker, WJ Racz… - … journal of cancer, 1987 - Wiley Online Library
Dietary 2‐acetylaminofluorene (2‐AAF) coupled with a stimulus for cell proliferation such as
a 2/3 partial hepatectomy (PH) or a necrotizing dose of carbon tetrachloride is frequently …
a 2/3 partial hepatectomy (PH) or a necrotizing dose of carbon tetrachloride is frequently …
The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity
SGW Wong, JW Card, WJ Racz - Toxicology letters, 2000 - Elsevier
Bromobenzene (BB) and furosemide (FS) are two hepatotoxicants whose bioactivation to
reactive intermediates is crucial to the development of liver injury. However, the events which …
reactive intermediates is crucial to the development of liver injury. However, the events which …
[PDF][PDF] Acetaminophen‐induced hepatotoxic congestion in mice
RM Walker, WJ Racz, TF McElligott - Hepatology, 1985 - Wiley Online Library
Acetaminophen‐induced (750 mg per kg po) hepatotoxicity in mice is characterized by
hepatomegaly and massive centrilobular congestion which precede the appearance of necrosis. …
hepatomegaly and massive centrilobular congestion which precede the appearance of necrosis. …
Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-β1 gene expression but not …
JW Card, WJ Racz, JF Brien, TE Massey - Journal of Pharmacology and …, 2003 - ASPET
Amiodarone (AM) is an efficacious antidysrhythmic agent that can cause numerous adverse
effects, including potentially life-threatening pulmonary fibrosis. The current study was …
effects, including potentially life-threatening pulmonary fibrosis. The current study was …
Acetaminophen-induced hypothermia, hepatic congestion, and modification by N-acetylcysteine in mice
…, TE Massey, TF McElligott, WJ Racz - Toxicology and Applied …, 1981 - Elsevier
Acetaminophen-induced hypothermia and hepatic congestion, their modification by N-acetylcysteine
(NAC) and their relationship to hepatotoxicity were studied in Swiss white mice. …
(NAC) and their relationship to hepatotoxicity were studied in Swiss white mice. …
Induction of c-jun and TGF-β1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis
WH Chung, BM Bennett, WJ Racz… - … of Physiology-Lung …, 2001 - journals.physiology.org
Amiodarone (AM) is an antidysrhythmic agent with a propensity to cause pulmonary toxicity,
including potentially fatal fibrosis. In the present study, the potential roles of c-Jun and …
including potentially fatal fibrosis. In the present study, the potential roles of c-Jun and …
Metal ion-biomolecule interactions. Synthesis, spectroscopic, and magnetic resonance investigations of methylmercury (II) complexes of the nucleosides guanosine …
E Buncel, AR Norris, WJ Racz, SE Taylor - Inorganic Chemistry, 1981 - ACS Publications
Solid complexes of the type [MeHg (NucH2)] N03,[MeHg (NucH)], and [(MeHg) 2 (NucH)]
N03 (NucH2= guanosine or inosine) have been prepared by the reaction of the nucleosides …
N03 (NucH2= guanosine or inosine) have been prepared by the reaction of the nucleosides …
Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells
…, BC Hill, T Takahashi, JF Brien, WJ Racz… - Toxicology and applied …, 2008 - Elsevier
Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM-induced …
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM-induced …