Endothelial cells release several compounds, including prostacyclin, NO, and endothelium-derived
hyperpolarizing factor (EDHF), that mediate the vascular effects of vasoactive …

Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian
tissues. Although selective antagonists are available for each of the subtypes, most of the …

N‐Arachidonoylethanolamine (anandamide, AEA) is a putative endogenous ligand of the
cannabinoid receptor. Intact cerebellar granule neurons in primary culture rapidly accumulate …

The CB1 subtype of the cannabinoid receptor is present on neurons in the brain and mediates
the perceptual effects of Δ 9 -tetrahydrocannabinol and other cannabinoids. We found that …

Microglia, as phagocytes and antigen-presenting cells in the central nervous system, are
activated in such disease processes as stroke and multiple sclerosis. Because peripheral …

In the brain, pressure-induced myogenic constriction of cerebral arteriolar muscle contributes
to autoregulation of cerebral blood flow (CBF). This study examined the role of 20-HETE in …

Endogenous modulators of platelet aggregability and vascular tone may play a part in
coronary-artery disease. We therefore measured the release of prostaglandins and thromboxane …

Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that
are produced by the vascular endothelium in response to agonists such as bradykinin and …

Background— Left internal mammary arteries (LIMAs) synthesize endothelium-derived
hyperpolarizing factor (EDHF), a short-lived K + channel activator that persists after inhibition of …

The endothelium regulates vascular tone through the release of a number of soluble
mediators, including NO, prostaglandin I 2 , and endothelium-derived hyperpolarizing factor. …