Assessment of renal autoregulation

WA Cupples, B Braam - American Journal of Physiology …, 2007 - journals.physiology.org
The kidney displays highly efficient autoregulation so that under steady-state conditions
renal blood flow (RBF) is independent of blood pressure over a wide range of pressure. …

Systemic arterial and venous determinants of renal hemodynamics in congestive heart failure

B Braam, WA Cupples, JA Joles, C Gaillard - Heart failure reviews, 2012 - Springer
Heart and kidney interactions are fascinating, in the sense that failure of the one organ
strongly affects the function of the other. In this review paper, we analyze how principal driving …

Nephron blood flow dynamics measured by laser speckle contrast imaging

…, AN Pavlov, WA Cupples… - American Journal …, 2011 - journals.physiology.org
Tubuloglomerular feedback (TGF) has an important role in autoregulation of renal blood flow
and glomerular filtration rate (GFR). Because of the characteristics of signal transmission in …

Tubuloglomerular feedback synchronization in nephrovascular networks

T Zehra, WA Cupples, B Braam - Journal of the American Society …, 2021 - journals.lww.com
To perform their functions, the kidneys maintain stable blood perfusion in the face of
fluctuations in systemic BP. This is done through autoregulation of blood flow by the generic …

Spontaneous blood pressure fluctuations and renal blood flow dynamics

WA Cupples, P Novak, V Novak… - American Journal of …, 1996 - journals.physiology.org
Two mechanisms operating at 0.03-0.05 and 0.1-0.2 Hz are involved in autoregulation of
renal blood flow (RBF). To examine the behavior of the faster system, the response of RBF to …

Tubuloglomerular feedback-dependent modulation of renal myogenic autoregulation by nitric oxide

…, X Wang, KH Chon, WA Cupples - American Journal of …, 2006 - journals.physiology.org
Nonselective inhibition of nitric oxide (NO) synthase (NOS) augments myogenic autoregulation,
an action that implies enhancement of pressure-induced constriction and dilatation. This …

Interactions contributing to kidney blood flow autoregulation

WA Cupples - Current opinion in nephrology and hypertension, 2007 - journals.lww.com
… 22 Wang X, Cupples WA. Interaction between nitric oxide and renal myogenic
autoregulation in normotensive and hypertensive rats. Can J Physiol Pharmacol 2001; 79:238–245 …

Dynamic autoregulation in the in vitro perfused hydronephrotic rat kidney

WA Cupples, RD Loutzenhiser - American Journal of …, 1998 - journals.physiology.org
Renal autoregulation is mediated by tubuloglomerular feedback, operating at 0.03–0.05 Hz,
and a faster system, operating at 0.1–0.2 Hz, that has been attributed by exclusion to …

Impaired myogenic autoregulation in kidneys of Brown Norway rats

…, FC Salevsky, WA Cupples - American Journal of …, 2000 - journals.physiology.org
The Brown Norway (BN) rat is normotensive and has an extended lifespan but is extremely
sensitive to hypertension-induced renal injury. Relative impairment of autoregulation has …

Responses of mesenteric and renal blood flow dynamics to acute denervation in anesthetized rats

…, H Bachelard, WA Cupples… - American Journal …, 1998 - journals.physiology.org
Previous studies have shown that renal autoregulation dynamically stabilizes renal blood
flow (RBF). The role of renal nerves, particularly of a baroreflex component, in dynamic …