[HTML][HTML] The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and-2
J Qi, W Lang, JG Geisler, P Wang, I Petrounia… - Journal of lipid …, 2012 - ASBMB
Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis.
There are two isoforms, DGAT1 and DGAT2, with distinct protein sequences and potentially …
There are two isoforms, DGAT1 and DGAT2, with distinct protein sequences and potentially …
The IC50 concept revisited
GW Caldwell, Z Yan, W Lang… - Current topics in …, 2012 - ingentaconnect.com
A major strategy used in drug design is the inhibition of enzyme activity. The ability to accurately
measure the concentration of the inhibitor which is required to inhibit a given biological …
measure the concentration of the inhibitor which is required to inhibit a given biological …
[HTML][HTML] Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity
…, A Wu, JA Zadrogra, AM Gajda, AI Lackey, W Lang… - Journal of lipid …, 2015 - ASBMB
Monoacylglycerol lipase (MGL) is a ubiquitously expressed enzyme that catalyzes the
hydrolysis of monoacylglycerols (MGs) to yield FFAs and glycerol. MGL contributes to energy …
hydrolysis of monoacylglycerols (MGs) to yield FFAs and glycerol. MGL contributes to energy …
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase
W Lang, C Qin, S Lin, AD Khanolkar… - Journal of medicinal …, 1999 - ACS Publications
Anandamide amidohydrolase (AAH) catalyzes the hydrolysis of arachidonylethanolamide (anandamide),
an endogenous cannabinoid receptor ligand. To delineate the structural …
an endogenous cannabinoid receptor ligand. To delineate the structural …
[HTML][HTML] Inter-laboratory reproducibility of an untargeted metabolomics GC–MS assay for analysis of human plasma
Y Lin, GW Caldwell, Y Li, W Lang, J Masucci - Scientific Reports, 2020 - nature.com
There is a long-standing concern for the lack of reproducibility of the untargeted metabolomic
approaches used in pharmaceutical research. Two types of human plasma samples were …
approaches used in pharmaceutical research. Two types of human plasma samples were …
Potent sodium/glucose cotransporter SGLT1/2 dual inhibition improves glycemic control without marked gastrointestinal adaptation or colonic microbiota changes in …
…, N Wallace, T Kirchner, M Jennis, W Lang… - … of Pharmacology and …, 2018 - ASPET
The sodium/glucose cotransporters (SGLT1 and SGLT2) transport glucose across the intestinal
brush border and kidney tubule. Dual SGLT1/2 inhibition could reduce hyperglycemia …
brush border and kidney tubule. Dual SGLT1/2 inhibition could reduce hyperglycemia …
[HTML][HTML] High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity
J Qi, W Lang, E Giardino, GW Caldwell, C Smith… - Journal of lipid …, 2010 - ASBMB
Acyl-CoA:diacylglycerol acyltransferase (DGAT) catalyzes the terminal step in triglyceride (TG)
synthesis using diacylglycerol (DAG) and fatty acyl-CoA as substrates. In the liver, the …
synthesis using diacylglycerol (DAG) and fatty acyl-CoA as substrates. In the liver, the …
High-performance liquid chromatographic determination of anandamide amidase activity in rat brain microsomes
W Lang, C Qin, WAG Hill, S Lin, AD Khanolkar… - Analytical …, 1996 - Elsevier
A rapid, sensitive, and reliable method for measuring anandamide amidase activity in rat brain
microsomes by reversed-phase high-performance liquid chromatography (RP-HPLC) and …
microsomes by reversed-phase high-performance liquid chromatography (RP-HPLC) and …
Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice
…, M Jennis, CR Cavanaugh, W Lang… - American Journal …, 2019 - journals.physiology.org
Trypsin is the major serine protease responsible for intestinal protein digestion. An inhibitor,
camostat (CS), reduced weight gain, hyperglycemia, and dyslipidemia in obese rats; …
camostat (CS), reduced weight gain, hyperglycemia, and dyslipidemia in obese rats; …
Biotransformation of geldanamycin and 17-allylamino-17-demethoxygeldanamycin by human liver microsomes: reductive versus oxidative metabolism and …
W Lang, GW Caldwell, J Li, GC Leo, WJ Jones… - Drug metabolism and …, 2007 - ASPET
Comparative metabolite profiling of geldanamycin and 17-allylamino-17-demethoxygeldanamycin
(17AAG) using human liver microsomes in normoxia and hypoxia was conducted to …
(17AAG) using human liver microsomes in normoxia and hypoxia was conducted to …