[PDF][PDF] Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.
GM Bores, FP Huger, W Petko, AE Mutlib… - … of Pharmacology and …, 1996 - researchgate.net
Acetylcholinesterase(AChE) inhibitors from several chemical classes have been tested for
the symptomatic treatment of Alzheimer’s disease; however, the therapeutic success of these …
the symptomatic treatment of Alzheimer’s disease; however, the therapeutic success of these …
IL-4, IL-10 and IL-13 modulate Aβ (1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line
AM Szczepanik, S Funes, W Petko… - Journal of …, 2001 - Elsevier
A hallmark of the immunopathology associated with Alzheimer’s disease (AD) is the presence
of activated microglia surrounding senile plaque deposits of β-amyloid (Aβ) peptides. Aβ …
of activated microglia surrounding senile plaque deposits of β-amyloid (Aβ) peptides. Aβ …
Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex
GE Ringheim, AM Szczepanik, W Petko… - Molecular Brain …, 1998 - Elsevier
We investigated a potential role for the soluble interleukin-6 receptor (sIL-6R) in modulating
interleukin-6 (IL-6) function in the central nervous system by assessing IL-6 and sIL-6R …
interleukin-6 (IL-6) function in the central nervous system by assessing IL-6 and sIL-6R …
Synthesis and Structure−Activity Relationships of N-Propyl-N-(4-pyridinyl)-1H-indol-1-amine (Besipirdine) and Related Analogs as Potential Therapeutic Agents for …
…, FP Huger, CP Smith, WW Petko… - Journal of medicinal …, 1996 - ACS Publications
A series of novel N-(4-pyridinyl)-1H-indol-1-amines and other heteroaryl analogs was
synthesized and evaluated in tests to determine potential utility for the treatment of Alzheimer's …
synthesized and evaluated in tests to determine potential utility for the treatment of Alzheimer's …
Imino 1, 2, 3, 4-tetrahydrocyclopent [b] indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase
…, BE Kurys, MC Merriman, GE Olsen, W Petko… - Bioorganic & Medicinal …, 1996 - Elsevier
A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated
as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen …
as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen …
Pharmacological activity and safety profile of P10358, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease
CP Smith, GM Bores, W Petko, M Li, DE Selk… - … of Pharmacology and …, 1997 - ASPET
1-[(3-Fluoro-4-pyridinyl)amino]-3-methyl-1(H)-indol-5-yl methyl carbamate (P10358) is a
potent, reversible acetylcholinesterase inhibitor that produces central cholinergic stimulation …
potent, reversible acetylcholinesterase inhibitor that produces central cholinergic stimulation …
Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl) amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel …
…, GE Olsen, GM Bores, F Camacho, WW Petko… - Bioorganic & Medicinal …, 1997 - Elsevier
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents
with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. …
with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. …
Transcriptional inhibition of the beta-amyloid precursor protein by interferon-gamma
…, AM Szcepanik, KL Burgher, W Petko… - Biochemical and …, 1996 - Elsevier
Attenuating beta-amyloid precursor protein (β-APP) gene expression may have relevance
in diseases such as Alzheimer's disease, where β-APP has been implicated in …
in diseases such as Alzheimer's disease, where β-APP has been implicated in …
Substituted (pyrroloamino) pyridines: potential agents for the treatment of Alzheimer's disease
…, FP Huger, CP Smith, WW Petko… - Journal of medicinal …, 1996 - ACS Publications
A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds
were evaluated for cholinomimetic-like properties in vitro (inhibition of [ 3 H]quinuclidinyl …
were evaluated for cholinomimetic-like properties in vitro (inhibition of [ 3 H]quinuclidinyl …
Additive effects of basic fibroblast growth factor and phorbol ester on β-amyloid precursor protein expression and secretion
GE RINGHEIM, S ASCHMIES, W PETKO - Neurochemistry international, 1997 - Elsevier
Expression of the β-amyloid precursor protein (β-APP), a proteoglycan whose proteolytically
derived fragments have been implicated in the neuropathology observed in Alzheimer's …
derived fragments have been implicated in the neuropathology observed in Alzheimer's …