[HTML][HTML] TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells
W Namkung, PW Phuan, AS Verkman - Journal of Biological Chemistry, 2011 - ASBMB
TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). We developed
pharmacological tools to investigate the contribution of TMEM16A to CaCC conductance in …
pharmacological tools to investigate the contribution of TMEM16A to CaCC conductance in …
An overview of KSTAR results
Since the first H-mode discharges in 2010, the duration of the H-mode state has been extended
and a significantly wider operational window of plasma parameters has been attained. …
and a significantly wider operational window of plasma parameters has been attained. …
The KSTAR project: An advanced steady state superconducting tokamak experiment
…, YS Bae, HS Kang, GN Kim, IS Ko, W Namkung… - Nuclear …, 2000 - iopscience.iop.org
The Korea Superconducting Tokamak Advanced Research (KSTAR) project is the major
effort of the national fusion programme of the Republic of Korea. Its aim is to develop a steady …
effort of the national fusion programme of the Republic of Korea. Its aim is to develop a steady …
Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells
…, VM Lynch, J Park, W Namkung, W Van Rossom… - Nature …, 2014 - nature.com
Anion transporters based on small molecules have received attention as therapeutic agents
because of their potential to disrupt cellular ion homeostasis. However, a direct correlation …
because of their potential to disrupt cellular ion homeostasis. However, a direct correlation …
Design and construction of the KSTAR tokamak
The extensive design effort for KSTAR has been focused on two major aspects of the KSTAR
project mission-steady-state-operation capability and advanced tokamak physics. The …
project mission-steady-state-operation capability and advanced tokamak physics. The …
[HTML][HTML] Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea
W Namkung, JR Thiagarajah, PW Phuan… - The FASEB …, 2010 - ncbi.nlm.nih.gov
TMEM16A was found recently to be a calcium-activated Cl− channel (CaCC). CaCCs perform
important functions in cell physiology, including regulation of epithelial secretion, cardiac …
important functions in cell physiology, including regulation of epithelial secretion, cardiac …
[HTML][HTML] Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
W Namkung, Z Yao, WE Finkbeiner… - The FASEB …, 2011 - ncbi.nlm.nih.gov
TMEM16A (ANO1) is a calcium-activated chloride channel (CaCC) expressed in secretory
epithelia, smooth muscle, and other tissues. Cell-based functional screening of∼ 110,000 …
epithelia, smooth muscle, and other tissues. Cell-based functional screening of∼ 110,000 …
Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
R De La Fuente, W Namkung, A Mills… - Molecular pharmacology, 2008 - ASPET
Calcium-activated chloride channels (CaCCs) are widely expressed in mammalian tissues,
including intestinal epithelia, where they facilitate fluid secretion. Potent, selective CaCC …
including intestinal epithelia, where they facilitate fluid secretion. Potent, selective CaCC …
Dynamic regulation of CFTR bicarbonate permeability by [Cl−] i and its role in pancreatic bicarbonate secretion
BACKGROUND & AIMS: Pancreatic bicarbonate (HCO 3 − ) secretion is important for a
healthy pancreas as well as digestive physiology. However, how human pancreatic duct cells …
healthy pancreas as well as digestive physiology. However, how human pancreatic duct cells …
A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations
Perturbations in cellular chloride concentrations can affect cellular pH and autophagy and
lead to the onset of apoptosis. With this in mind, synthetic ion transporters have been used to …
lead to the onset of apoptosis. With this in mind, synthetic ion transporters have been used to …