The potential of the diverse chemistries present in natural products (NP) for biotechnology
and medicine remains untapped because NP databases are not searchable with raw data …

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi
and plants are known to be encoded in biosynthetic gene clusters. Information about these …

The chemical and biological diversity of the marine environment is immeasurable and
therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent …

Marine life forms are an important source of structurally diverse and biologically active
secondary metabolites, several of which have inspired the development of new classes of …

A major goal in natural product discovery programs is to rapidly dereplicate known entities
from complex biological extracts. We demonstrate here that molecular networking, an …

Metabolomics using nontargeted tandem mass spectrometry can detect thousands of molecules
in a biological sample. However, structural molecule annotation is limited to structures …

A screening program for bioactive compounds from marine cyanobacteria led to the isolation
of jamaicamides A–C. Jamaicamide A is a novel and highly functionalized lipopeptide …

Understanding of the capacity of the natural world to produce secondary metabolites is
important to a broad range of fields, including drug discovery, ecology, biosynthesis, and …

Despite knowledge of the existence of the pigment called scytonemin for over 100 years, its
structure has remained unsolved until now. This pigment, the first shown to be an effective, …

Bioassay-guided fractionation of the organic extract of a Curasao collection of Lyngbya
majuscula led to the isolation of a new lipid, curacin A, with exceptional brine shrimp toxic and …