Stroke is one of the leading causes of death and disability worldwide. It is well known that
hyperglycemia and/or diabetes potentially exacerbate the neuronal damage observed …

… Mice were injected with 10ml of 5% formalin [formaldehyde solution 37% (w/w) diluted in
saline] into the subplantar space of the right hind paw 30 min after the treatment of DHA (po). …

… 8 Harada S, Fujita-Hamabe W, Tokuyama S. The importance of regulation of blood glucose
levels through activation of peripheral 5[2019]-AMP-activated protein kinase on ischemic …

Matrix metalloproteinase-9 (MMP-9) is involved in tissue remodeling or neural plasticity in
various clinical states (eg inflammation, neuropathic pain). We focused on the effect of MMP-9 …

AIMS: P-glycoprotein (P-gp) is an important drug efflux transporter located in many tissues
such as the blood–brain barrier, intestines, liver and kidneys. We have previously reported …

5′-AMP-activated protein kinase (AMPK) is a serine/threonine kinase that plays a key role
in energy homeostasis. Recently, it was reported that centrally activated AMPK is involved in …

Objectives Cerebral ischaemia is a leading cause of death and disability, including severe
complications such as memory disturbance, palsy, and spasticity. Central post-stroke pain (…

Neural cell adhesion molecule (NCAM) is a membrane protein abundantly expressed in the
central nervous system. Recently, it has been reported that dysfunction of NCAM is linked to …

… Mice were injected with 10ml of 5% formalin [formaldehyde solution 37% (w/w) diluted in
saline] into the subplantar space of the right hind paw 30 min after the treatment of the CHCl3-…

Neural cell adhesion molecule (NCAM) is a member of the immunoglobulin superfamily with
an important function in the central nervous system, particularly in synapse stabilization and …