Understanding precisely how the heart can recognize and respond to many different extracellular
signalling molecules, such as neurotransmitters, hormones and growth factors, will aid …

Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

Intracranial aneurysms (IAs) linger as a potentially devastating clinical problem. Despite
intense investigation, our understanding of the mechanisms leading to aneurysm development, …

According to Reiss and McNally's expectancy theory, a high level of anxiety sensitivity (“fear
of anxiety”) increases the risk for anxiety disorders, and plays a particularly important role in …

… WJ Koch et al., unpublished data. For construction of the lARK1 transgene, a 5.5-kb Sac I-Hind
Ill fragment, the a-MHC promoter, was isolated [A. Subramanian et al., J. …

Erythropoietin (EPO) has been shown to protect neurons from ischemic stroke, but can also
increase thrombotic events and mortality rates in patients with ischemic heart disease. We …

Rationale: Embryonic stem cells (ESCs) hold great promise for cardiac regeneration but are
susceptible to various concerns. Recently, salutary effects of stem cells have been …

Complementary DNAs were isolated and used to deduce the primary structures of the α 1
and α 2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel from …

Rationale: Coronary artery ligation to induce myocardial infarction (MI) in mice is typically
performed by an invasive and time-consuming approach that requires ventilation and chest …

Heart failure is accompanied by severely impaired β-adrenergic receptor (βAR) function,
which includes loss of βAR density and functional uncoupling of remaining receptors. An …