Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

A Bhattacharjee, WG Richards… - Proceedings of the …, 2001 - National Acad Sciences
We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer
death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed …

Dickkopf-1 is a master regulator of joint remodeling

…, R Landewe, D Lacey, WG Richards… - Nature medicine, 2007 - nature.com
Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture.
Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid …

Leptin regulation of bone resorption by the sympathetic nervous system and CART

…, M Starbuck, X Yang, X Liu, H Kondo, WG Richards… - Nature, 2005 - nature.com
Bone remodelling, the mechanism by which vertebrates regulate bone mass, comprises two
phases, namely resorption by osteoclasts and formation by osteoblasts; osteoblasts are …

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

…, Y Gong, L Martin, JC Louis, Q Yan, WG Richards… - Nature …, 2001 - nature.com
Mice deficient in BACE1 (beta-site APP cleaving enzyme 1) are healthy, fertile and appear
normal in gross anatomy, tissue histology, hematology and clinical chemistry. BACE1−/− mice …

[HTML][HTML] Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

…, GS Herter-Sprie, KA Buczkowski, WG Richards… - Nature …, 2016 - nature.com
Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1):
programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to …

EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer

…, J Kim, D Chiang, R Thomas, J Lee, WG Richards… - Clinical cancer …, 2008 - AACR
Purpose: The EML4-ALK fusion gene has been detected in ∼7% of Japanese non-small cell
lung cancers (NSCLC). We determined the frequency of EML4-ALK in Caucasian NSCLC …

[HTML][HTML] Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural …

…, RM Flores, MT Jaklitsch, WG Richards… - The Journal of thoracic …, 1999 - Elsevier
Objectives: Our aim was to identify prognostic variables for long-term postoperative survival
in trimodality management of malignant pleural mesothelioma. Methods: From 1980 to 1997, …

Translation of microarray data into clinically relevant cancer diagnostic tests using gene expression ratios in lung cancer and mesothelioma

…, JE Blumenstock, S Ramaswamy, WG Richards… - Cancer research, 2002 - AACR
The pathological distinction between malignant pleural mesothelioma (MPM)and adenocarcinoma
(ADCA) of the lung can be cumbersome using established methods. We propose that …

[PDF][PDF] Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species

…, CV Meyerovitz, CM Kerwin, S Choi, WG Richards… - Immunity, 2019 - cell.com
Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells,
and neutrophils, and have emerged as key regulators of cancer growth. These cells can …

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

…, DJ Sugarbaker, FJ de Sauvage, WG Richards… - Nature …, 2016 - nature.com
We analyzed transcriptomes (n = 211), whole exomes (n = 99) and targeted exomes (n =
103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …