In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies
…, S Chen, K He, TC Goosen, WH Griffith… - Drug Metabolism and …, 2010 - ASPET
Apixaban is an oral, direct, and highly selective factor Xa inhibitor in late-stage clinical
development for the prevention and treatment of thromboembolic diseases. The metabolic drug-…
development for the prevention and treatment of thromboembolic diseases. The metabolic drug-…
Spatial reference and working memory across the lifespan of male Fischer 344 rats
…, AN McDermott, B Setlow, WH Griffith - Neurobiology of …, 2009 - Elsevier
Loss of mnemonic function is among the earliest and most disconcerting consequences of
the aging process. This study was designed to provide a comprehensive profile of spatial …
the aging process. This study was designed to provide a comprehensive profile of spatial …
Calcium buffering systems and calcium signaling in aged rat basal forebrain neurons
D Murchison, WH Griffith - Aging cell, 2007 - Wiley Online Library
Disturbances of neuronal Ca 2+ homeostasis are considered to be important determinants
of age‐related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are …
of age‐related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are …
Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice
LS Dove, LC Abbott, WH Griffith - Journal of Neuroscience, 1998 - Soc Neuroscience
The leaner (tg la ) mutation in mice results in severe ataxia and an overt neurodegeneration
of the cerebellum. Positional cloning has revealed that the tg la mutation occurs in a gene …
of the cerebellum. Positional cloning has revealed that the tg la mutation occurs in a gene …
Chapter Membrane currents in hippocampal neurons
DA Brown, BH Gähwiler, WH Griffith… - Progress in brain research, 1990 - Elsevier
This chapter reviews properties and functions of endogenous ionic currents in hippocampal
neurones. Currents considered are: Na currents I Na(fast) and I Na(slow) ; Ca currents; K …
neurones. Currents considered are: Na currents I Na(fast) and I Na(slow) ; Ca currents; K …
Calcium‐activated outward current in voltage‐clamped hippocampal neurones of the guinea‐pig.
DA Brown, WH Griffith - The Journal of Physiology, 1983 - Wiley Online Library
Slow clamp currents were recorded from CA1 and CA3 pyramidal neurones in slices of
guinea‐pig hippocampus maintained in vitro, using a single micro‐electrode sample‐and‐hold …
guinea‐pig hippocampus maintained in vitro, using a single micro‐electrode sample‐and‐hold …
Electrophysiology of AChE-positive neurons in basal forebrain slices
WH Griffith, RT Matthews - Neuroscience letters, 1986 - Elsevier
We have utilized a guinea pig in vitro brain slice preparation of the medial septum (MS) and
the vertical and horizontal limbs of the nucleus of the diagonal band of Broca (nDBB) to …
the vertical and horizontal limbs of the nucleus of the diagonal band of Broca (nDBB) to …
Deficits across multiple cognitive domains in a subset of aged Fischer 344 rats
…, KS Montgomery, C Tucker, GS Slaton, WH Griffith… - Neurobiology of …, 2007 - Elsevier
Rodent models of cognitive aging routinely use spatial performance on the water maze to
characterize medial temporal lobe integrity. Water maze performance is dependent upon this …
characterize medial temporal lobe integrity. Water maze performance is dependent upon this …
Toxicity of air-oxidized soybean oil
JS Andrews, WH Griffith, JF Mead, RA Stein - The Journal of Nutrition, 1960 - Elsevier
The toxicity of air-oxidized soybean oil to weanling rats was investigated in several aspects.
Growth studies demonstrated that the concentration of the toxic principle corresponded …
Growth studies demonstrated that the concentration of the toxic principle corresponded …
Increased calcium buffering in basal forebrain neurons during aging
D Murchison, WH Griffith - Journal of neurophysiology, 1998 - journals.physiology.org
… Griffith. Increased calcium buffering in basal forebrain neurons during aging. J. … suggesting
that CICR is not a prominent feature in these cells (Murchison and Griffith, unpublished data). …
that CICR is not a prominent feature in these cells (Murchison and Griffith, unpublished data). …