The primary safety concern for DNA vaccines is their potential to integrate into the host cell
genome. We describe an integration assay based on purification of high-molecular-weight …

A variety of factors could affect the frequency of integration of plasmid DNA vaccines into host
cellular DNA, including DNA sequences within the plasmid, the expressed gene product (…

… Ventral prostate homogenates were prepared as a 25% (w/v) homogenate (protein
concentration 25 mgiml). Fetal genital tubercles from several litters were collected with the aid of a …

The primary safety concern for DNA vaccines is their potential to integrate into host cellular
DNA. We describe a sensitive and quantitative assay for investigating the tissue distribution …

… Studies in dogs and man have shown that blockade of the 5c-w-reductase enzyme lowers
the intraprostatic and serum DHT levels, and can cause a decrease of the size of the prostate […

… PRAHALADA, JA MAJKA, KA SOPER, TM NETT,* WJ BAGDON, CP PETER, JD BUREK, JS
… Laroque, PA, Prahalada, S., Gordon, LR, Molon-Noblot, S., Bagdon, WJ, Duprat, P., Peter, …

Diflunisal, a new salicylate, possesses anti-inflammatory, analgesic and antipyretic activity.
It was found to be about 7.5-13 times more active than aspirin as an analgesic (Randall-…

Alendronate (4-amino-1-hydroxybutylidene bisphosphonate, ALN) is an aminobisphosphonate
that is being developed for the treatment of diseases characterized by increased bone …

Diltiazem (DTZ), a calcium channel blocker, and enalapril (EN), an angiotensin-converting
enzyme inhibitor, are being developed as combination therapy for cardiovascular disease. A …

Manor Farms SPF and Charles River CD rats were given a nonsteroid antiinflammatory agent
(1-p-chlorobenzylidine-5-methoxy-2-methyl-3-indeneacetic acid) po, at dose levels of 3, 6, …