Chronic kidney disease, cancer, chronic inflammatory disorders, nutritional, and genetic
deficiency can cause anemia. Hypoxia causes induction of hypoxia-inducible factor (HIF), which …

The nuclear receptor retinoic acid receptor-related orphan receptor gamma (RORγ or RORc)
is a key transcription factor for the production of pro-inflammatory cytokines implicated in …

Receptor-interacting protein kinase 2 (RIP2 or RICK, herein referred to as RIPK2) is linked
to the pathogen pathway that activates nuclear factor κ-light-chain-enhancer of activated B …

Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits
beneficial pleiotropic health effects. It is one of the most promising natural molecules in the …

Apoptosis is fundamental to normal animal development and is the target for many anticancer
therapies. Recent studies have explored the consequences of “failed apoptosis” where the …

A novel series of potent and efficacious factor Xa inhibitors which possesses sulfoximine
moiety as novel S4 binding element in anthranilamide chemotype has been identified. Lead …

Breast cancer is the leading cause of cancer-associated deaths in women worldwide.
Clinical biomarkers give information on disease progression and identify relevant biological …

A convenient and high-yielding synthesis of unsymmetrical dibenzothiophenes has been
achieved by an acid-mediated ring closure of the biphenyl ring having a sulfoxide substituent …

Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways.
Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland …

Background and Objectives Desidustat is a novel prolyl hydroxylase domain (PHD) inhibitor
for the treatment of anemia. The objective of this study was to investigate the …