For most cancers, the treatment of choice is still chemotherapy despite its severe adverse
effects, systemic toxicity and limited efficacy due to the development of multidrug resistance (…

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is
the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp)…

Breast cancer is the most frequent malignancy in women. Multidrug resistance due to
overexpression of ABC drug transporters is a common cause of chemotherapy failure and disease …

The canalicular membrane represents the excretory pole of hepatocytes. Bile is an important
route of elimination of potentially toxic endo-and xenobiotics (including drugs and toxins), …

We evaluated the effect of spironolactone (SL), a well-known inducer of biotransformation
and elimination pathways, on the expression and activity of P-glycoprotein (P-gp/ABCB1/…

ABC transporters including MRP2, MDR1 and BCRP play a major role in tissue defense.
Epidemiological and experimental studies suggest a cytoprotective role of estrogens in intestine…

P-glycoprotein (P-gp) is an ABC transporter exhibiting high pharmacotoxicological
relevance by extruding a wide range of cytotoxic compounds out of the cells. Previously, we …

We evaluated the effect of acetaminophen (APAP), given as a single, 1g/kg body weight dose,
on expression and activity of rat liver multidrug resistance-associated protein 2 (Mrp2) and …

The molecular basis of perinatal changes occurring in major UDP-glucuronosyltransferase (UGT)
family 1 isoforms and in UGT2B1, a relevant isoform belonging to family 2, was …

Development of resistance to toxic effects of acetaminophen (APAP) was reported in rodents
and humans, though the mechanism is only partially understood. We examined in rats the …