Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming
the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract …

The most common aortopathies in women of childbearing age are bicuspid aortic valve,
coarctation of the aorta, Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome, …

Heart failure is characterized by the constant interplay between the underlying cardiac insult,
degree of myocardial dysfunction and the activity of compensatory neurohormonal …

Aim Patients with Marfan syndrome have an increased risk of life-threatening aortic
complications, mostly preceded by aortic dilatation. Treatment with losartan, an angiotensin-II …

von Willebrand factor (vWF) is frequently used as a biochemical marker for endothelial cells
(ECs). Despite this, little is known about the relative level of expression and regulation of this …

Objective— The purpose of this study was to evaluate the effect of the combined deletion of
ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis. …

Growth differentiation factor (GDF) 15 is a member of the transforming growth factor β (TGF-β)
superfamily, which operates in acute phase responses through a currently unknown …

Background— It has been shown that losartan reduces aortic dilatation in patients with
Marfan syndrome. However, treatment response is highly variable. This study investigates …

Background— Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis
and restenosis. The precise signaling pathways by which the proliferation of SMCs is …

Rationale: Nuclear receptor Nur77, also known as NR4A1, TR3, or NGFI-B, is expressed in
human atherosclerotic lesions in macrophages, endothelial cells, T cells and smooth muscle …