Cellular responses to xenobiotic-induced stress can signal proliferation, differentiation,
homeostasis, apoptosis, or necrosis. To better understand the underlying molecular mechanisms …

Many chemopreventive agents have been shown to modulate gene expression including
induction of phase II detoxifying enzymes, such as glutathione S-transferases (GST) and …

Antioxidant response element (ARE) regulates the induction of a number of cellular antioxidant
and detoxifying enzymes. However, the signaling pathways that lead to ARE activation …

Garlic organosulfur compounds (OSCs) are recognized as a group of potential chemopreventive
compounds. It is known that garlic OSCs can modulate drug metabolism systems, …

Epigallocatechin-3-gallate (EGCG), a major component in green tea polyphenols, has been
proven to suppress colonic tumorigenesis in animal models and epidemiological studies. As …

Sulforaphane (SUL) is one member of the isothiocyanate class of cancer chemopreventive
compounds that has been shown to be effective in blocking initiation and progression of …

Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II
detoxifying enzymes as well as anti-oxidative enzymes. In this study, we investigated the …

The purpose of this study was to compare the hepatic and small intestinal metabolism, and
to examine bioavailability and gastro‐intestinal first‐pass effects, of kaempferol in rats. Liver …

Sulforaphane (SFN) is an isothiocyanate that is present abundantly in widely consumed
cruciferous vegetables and has a particularly high content in broccoli and cauliflower. It has …

Phenethyl isothiocyanate (PEITC) is a potential chemopreventive agent that is present
naturally in widely consumed vegetables, especially in watercress. It has been extensively …