Advances in nanotechnology have favored the development of novel colloidal formulations
able to modulate the pharmacological and biopharmaceutical properties of drugs. The …

Liposomes are used as a delivery vehicle for drug molecules and imaging agents. The major
impetus in their biomedical applications comes from the ability to prolong their circulation …

3,5-Bis(benzylidene)-4-piperidones are being advanced as synthetic analogs of curcumin
for anti-cancer and anti-inflammatory properties. We performed structure–activity relationship …

Objectives: Nuclear factor κB (NF-κB) plays an intrinsic role in promoting growth, angiogenesis,
and metastasis in pancreatic cancer (PC) and serves as a mechanism underlying …

We report synthesis and characterization of a novel PEG 2000 -conjugated
hexadecylcarbamoylmethyl hexadecanoate (HDAS-PEG) as a PEG-phospholipid substitute for …

Prostate specific membrane antigen (PSMA) is a marker for diagnosis and targeted delivery
of therapeutics to advanced/metastasized prostate cancer. We report a liposome-based …

Lipids are essential components of the nervous system. However, the functions of very long-chain
fatty acids (VLC-FA; ≥ 28 carbons) in the brain are unknown. The enzyme …

Physiological alterations, anxiety, and cognitive disorders are strongly associated with blast-induced
traumatic brain injury (blast TBI), and are common symptoms in service personnel …

Nitric oxide-releasing aspirin (NO-aspirin) represents a novel class of promising chemopreventive
agents. Unlike conventional nonsteroidal anti-inflammatory drugs, NO-aspirin seems …

Tumor microenvironments (TMEs) are composed of cancer cells, fibroblasts, extracellular
matrix, microvessels, and endothelial cells. Two prolyl endopeptidases, fibroblast activation …