… appear to work as independent receptors, which have a lower affinity for pro-heparanase-1
(Kd =∼23.4 nM) but are ∼10 fold more abundant than the LRP-based receptors (Vreys et al.…

Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the
treatment of hematologic malignancies, but their activity in solid tumor indications has been …

Mammalian heparanase, strongly implicated in the regulation of cell growth, migration, and
differentiation, plays a crucial role in inflammation, angiogenesis, and metastasis. There is …

JNJ-26854165 (serdemetan) has previously been reported to inhibit the function of the E3
ligase human double minute 2, and we initially sought to characterize its activity in models of …

We have recently reported the identification and characterization of JNJ-26481585, as a “second
generation” oral pan-HDAC inhibitor. The compound has shown potent in vitro activity …

Background: Nebulizers are a potential source of contamination of the respiratory tract.
Nevertheless, only a few clear guidelines regarding cleaning and disinfection of nebulizers are …

Cells communicate with their environment in various ways, including by secreting vesicles.
Secreted vesicles are loaded with proteins, lipids and RNAs that compose ‘a signature’ of the …

268 Hygiene of the inhalation equipment: a Belgian national survey × Close The Infona portal
uses cookies, ie strings of text saved by a browser on the user's device. The portal can access …

267 Hygiene of the inhalation equipment: what about vibrating-mesh nebulizers? × Close
The Infona portal uses cookies, ie strings of text saved by a browser on the user's device. The …