The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely distributed
transmembrane protein that is located mainly in the outer mitochondrial membrane. The …

The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial
membrane of steroid-synthesizing cells, including those in the central and peripheral nervous …

Highlights • A thorough review of 14-3-3 protein function. • Discussion of 14-3-3 proteins in
health, disease, and animal models. • Review of 14-3-3 protein-targeted compounds, …

Background Recent epidemiological data indicate that there may be a gender predisposition
to COVID‐19, with men predisposed to being most severely affected, and older men …

Herein we summarize important discoveries made over many years about Leydig cell function
and regulation. Fetal Leydig cells produce the high levels of androgen (testosterone or …

Cholesterol transport from the outer to the inner mitochondrial membrane is the rate-determining
step in steroid and bile acid biosyntheses. Biochemical, pharmacological and …

Recent studies conducted with various molecular, cellular and whole animal models have
revealed that leaf extracts of Ginkgo biloba may have anticancer (chemopreventive) …

The transfer of cholesterol from the outer to the inner mitochondrial membrane is the rate-limiting
step in hormone-induced steroid formation. To ensure that this step is achieved …

In previous studies we demonstrated that peripheral-type benzodiazepine receptors (PBR)
were coupled to steroidogenesis in several adrenocortical and Leydig cell systems (Mukhin, …

In steroid-synthesizing cells, like the MA-10 mouse tumor Leydig cells, the peripheral-type
benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein involved in the …