Colchicine is a competitive antagonist at human recombinant γ-aminobutyric acidA receptors
Colchicine is an alkaloid that is used clinically in the treatment of arthritic gout. This potent
microtubule disrupting agent has also been used extensively as an experimental tool in …
microtubule disrupting agent has also been used extensively as an experimental tool in …
The cytoskeleton and neurotransmitter receptors
VJ Whatley, RA Harris - International review of neurobiology, 1996 - Elsevier
Publisher Summary The cytoskeleton is essential for the optimization of efficient synaptic
transmission. This chapter discusses the role of the cytoskeleton in the clustering and function …
transmission. This chapter discusses the role of the cytoskeleton in the clustering and function …
Gamma-aminobutyric acidA receptor function is inhibited by microtubule depolymerization.
VJ Whatley, SJ Mihic, AM Allan, SJ McQuilkin… - Journal of Biological …, 1994 - Elsevier
Microtubules are present at postsynaptic densities in brain and are proposed to be involved
in anchoring neurotransmitter receptor clusters at postsynaptic membranes. However, the …
in anchoring neurotransmitter receptor clusters at postsynaptic membranes. However, the …
Identification and confirmation of quantitative trait loci regulating alcohol consumption in congenic strains of mice
VJ Whatley, TE Johnson… - Alcoholism: Clinical and …, 1999 - Wiley Online Library
Background:C57BL/6 inbred mice prefer alcohol whereas DBA/2 mice avoid it. We describe
the construction of congenic strains of mice in which DBA/2 alleles for alcohol avoidance …
the construction of congenic strains of mice in which DBA/2 alleles for alcohol avoidance …
Microtubule Depolymerization Inhibits Ethanol‐Induced Enhancement of GABAA Responses in Stably Transfected Cells
VJ Whatley, SJ Brozowski… - Journal of …, 1996 - Wiley Online Library
We studied whether microtubule organization is important for actions of ethanol on GABA A
ergic responses by testing the effects of microtubule depolymerization on ethanol …
ergic responses by testing the effects of microtubule depolymerization on ethanol …
β‐Lumicolchicine Interacts with the Benzodiazepine Binding Site to Potentiate GABAA Receptor‐Mediated Currents
SJ Mihic, VJ Whatley, SJ McQuilkin… - Journal of …, 1994 - Wiley Online Library
An analogue of colchicine,β‐lumicolchicine, does not bind tubulin or disrupt microtubules.
However, this compound is not pharmacologically completely inactive. β‐Lumicolchicine was …
However, this compound is not pharmacologically completely inactive. β‐Lumicolchicine was …
Stable expression of human glycine α1 and α2 homomeric receptors in mouse L (tk−) cells
MJ Wick, V Bleck, VJ Whatley, SJ Brozowski… - Journal of neuroscience …, 1999 - Elsevier
We report the development of two mouse fibroblast-like stably-transfected cell lines (α1-62-4
and α2-B36-1) that express human α 1 or α 2 glycine receptor subunits, respectively. …
and α2-B36-1) that express human α 1 or α 2 glycine receptor subunits, respectively. …
The role of microtubules in GABA (A) ergic function and anchoring GABA (A) receptors in plasma membrane
VJ Whatley - 1996 - search.proquest.com
Microtubules are present at postsynaptic densities in brain and interact with integral proteins
in postsynaptic membranes (Gordon-Weeks et al., 1976). This dissertation focused on the …
in postsynaptic membranes (Gordon-Weeks et al., 1976). This dissertation focused on the …
Microtubule depolyroerization disaggregates GABAA receptor clustering and inhibits GABAA ergic function in stably transfected cells: 20.17
VJ Whatley, SJ Brozowski, PJ Whiting… - Behavioural …, 1995 - journals.lww.com
… Whatley, VJ; Brozowski, SJ; Whiting, PJ; Harris, RA … Articles in PubMed by VJ Whatley …
Other articles in this journal by VJ Whatley …
Other articles in this journal by VJ Whatley …
[CITATION][C] A possible role of GABAA clustering in ethanol enhancement of GABAA-ergic function
VJ Whatley, SJ Brozowski, JL Weiner, TV Dunwiddie… - Alcohol Clin. exp. Res. S, 1995