Colchicine is a competitive antagonist at human recombinant γ-aminobutyric acidA receptors

JL Weiner, AV Buhler, VJ Whatley, RA Harris… - … of Pharmacology and …, 1998 - ASPET
Colchicine is an alkaloid that is used clinically in the treatment of arthritic gout. This potent
microtubule disrupting agent has also been used extensively as an experimental tool in …

The cytoskeleton and neurotransmitter receptors

VJ Whatley, RA Harris - International review of neurobiology, 1996 - Elsevier
Publisher Summary The cytoskeleton is essential for the optimization of efficient synaptic
transmission. This chapter discusses the role of the cytoskeleton in the clustering and function …

Gamma-aminobutyric acidA receptor function is inhibited by microtubule depolymerization.

VJ Whatley, SJ Mihic, AM Allan, SJ McQuilkin… - Journal of Biological …, 1994 - Elsevier
Microtubules are present at postsynaptic densities in brain and are proposed to be involved
in anchoring neurotransmitter receptor clusters at postsynaptic membranes. However, the …

Identification and confirmation of quantitative trait loci regulating alcohol consumption in congenic strains of mice

VJ Whatley, TE Johnson… - Alcoholism: Clinical and …, 1999 - Wiley Online Library
Background:C57BL/6 inbred mice prefer alcohol whereas DBA/2 mice avoid it. We describe
the construction of congenic strains of mice in which DBA/2 alleles for alcohol avoidance …

Microtubule Depolymerization Inhibits Ethanol‐Induced Enhancement of GABAA Responses in Stably Transfected Cells

VJ Whatley, SJ Brozowski… - Journal of …, 1996 - Wiley Online Library
We studied whether microtubule organization is important for actions of ethanol on GABA A
ergic responses by testing the effects of microtubule depolymerization on ethanol …

β‐Lumicolchicine Interacts with the Benzodiazepine Binding Site to Potentiate GABAA Receptor‐Mediated Currents

SJ Mihic, VJ Whatley, SJ McQuilkin… - Journal of …, 1994 - Wiley Online Library
An analogue of colchicine,β‐lumicolchicine, does not bind tubulin or disrupt microtubules.
However, this compound is not pharmacologically completely inactive. β‐Lumicolchicine was …

Stable expression of human glycine α1 and α2 homomeric receptors in mouse L (tk−) cells

MJ Wick, V Bleck, VJ Whatley, SJ Brozowski… - Journal of neuroscience …, 1999 - Elsevier
We report the development of two mouse fibroblast-like stably-transfected cell lines (α1-62-4
and α2-B36-1) that express human α 1 or α 2 glycine receptor subunits, respectively. …

The role of microtubules in GABA (A) ergic function and anchoring GABA (A) receptors in plasma membrane

VJ Whatley - 1996 - search.proquest.com
Microtubules are present at postsynaptic densities in brain and interact with integral proteins
in postsynaptic membranes (Gordon-Weeks et al., 1976). This dissertation focused on the …

Microtubule depolyroerization disaggregates GABAA receptor clustering and inhibits GABAA ergic function in stably transfected cells: 20.17

VJ Whatley, SJ Brozowski, PJ Whiting… - Behavioural …, 1995 - journals.lww.com
Whatley, VJ; Brozowski, SJ; Whiting, PJ; Harris, RA … Articles in PubMed by VJ Whatley
Other articles in this journal by VJ Whatley

[CITATION][C] A possible role of GABAA clustering in ethanol enhancement of GABAA-ergic function

VJ Whatley, SJ Brozowski, JL Weiner, TV Dunwiddie… - Alcohol Clin. exp. Res. S, 1995