The biological activity of natural and semisynthetic lupane triterpenoids is discussed in a two-part
review. The first part is devoted to the pharmacological properties of natural lupane …

Reactions of aromatic Schiff bases with alkenes affording substituted 1, 2, 3, 4-
tetrahydroquinolines are reviewed. The synthetic potential and the mechanisms of reactions …

Widespread application of omic technologies is evolving our understanding of population
health and holds promise in providing precise guidance for selection of therapeutic …

Conventional wisdom holds that microbes support their growth in vertebrate hosts by
exploiting a large variety of nutrients. We show here that use of a specific nutrient (ethanolamine) …

The primary goal of metabolomic analysis is the unbiased relative quantification of every
metabolite in a biological system. A number of different metabolite-profiling techniques must be …

The diagnosis of cancer by examination of the urine has the potential to improve patient
outcomes by means of earlier detection. Due to the fact that the urine contains metabolic …

Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro.
Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-…

Sulfur is an essential macroelement in plant and animal nutrition. Plants assimilate inorganic
sulfate into two sulfur-containing amino acids, cysteine and methionine. Low supply of …

Plastid-derived signals are known to coordinate expression of nuclear genes encoding
plastid-localized proteins in a process termed retrograde signaling. To date, the identity of …

10.7554/eLife.13442.001 Gene-environment interactions impact the development of
neuropsychiatric disorders, but the relative contributions are unclear. Here, we identify gut …