(–)-(1R, 2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel μ-opioid receptor agonist/norepinephrine reuptake inhibitor …

…, W Englberger, M Haurand, U Jahnel… - Journal of pharmacology …, 2007 - ASPET
(–)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol
HCl) is a novel μ-opioid receptor (MOR) agonist (K i = 0.1 μM; relative efficacy compared …

Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist

…, W Englberger, S Schunk, J De Vry, U Jahnel… - … of Pharmacology and …, 2014 - ASPET
Cebranopadol (trans-6′-fluoro-4′,9′-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1′(3′H)-pyrano[3,4-b]indol]-4-amine)
is a novel analgesic nociceptin/orphanin FQ …

Synergistic interaction between the two mechanisms of action of tapentadol in analgesia

…, TM Tzschentke, R Terlinden, J De Vry, U Jahnel… - … of Pharmacology and …, 2011 - ASPET
The novel centrally acting analgesic tapentadol [(−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
hydrochloride] combines two mechanisms of action, μ-opioid receptor (…

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

W Schroeder, J De Vry, TM Tzschentke, U Jahnel… - European Journal of …, 2010 - Elsevier
The novel analgesic tapentadol combines μ-opioid receptor agonism and noradrenaline
reuptake inhibition in a single molecule and shows potent analgesia in various rodent models …

Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule.

TM Tzschentke, U Jahnel, B Kogel… - Drugs of today …, 2009 - europepmc.org
Tapentadol exerts its analgesic effects through micro opioid receptor agonism and noradrenaline
reuptake inhibition in the central nervous system. Preclinical studies demonstrated that …

Positive inotropic response to 5-HT in human atrial but not in ventricular heart muscle

U Jahnel, J Rupp, R Ertl, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1992 - Springer
The effects of 5-hydroxytryptamine (5-HT) on force of contraction (F C ), action potential (AP)
and calcium current (I Ca ) were studied in human right atrial and left ventricular heart …

Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs

…, R Hauser, JO Andreas, K Linz, U Jahnel - European Journal of …, 2005 - Elsevier
The effects of drugs that inhibit human ether-a-go-go-related gene (HERG) related cardiac
potassium channels on the variability of QT duration as a sign of repolarisation instability …

Differential electrophysiologic and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats

R Ertl, U Jahnel, H Nawrath, E Carmeliet… - Naunyn-Schmiedeberg's …, 1991 - Springer
Stimulation of α 1 -adrenoceptors evokes a different pattern of inotropic responses in atrial
and ventricular heart muscle preparations from rats. The inotropic effects are accompanied by …

Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes

U Jahnel, P Klemm, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1994 - Springer
The mechanism of drug-induced inhibition of the transient outward current, I to , has been
investigated in rat ventricular myocytes using the whole cell patch clamp technique. I to was …

L-type calcium channel activity in human atrial myocytes as influenced by 5-HT

U Jahnel, H Nawrath, J Rupp, R Ochi - Naunyn-Schmiedeberg's archives …, 1993 - Springer
5-Hydroxytryptamine (10 μmol/l; 5-HT) exerted a positive inotropic effect associated with an
increase in the Ca 2+ current (I Ca ) in the human right atrium. For detailed analysis, L-type …