Tapentadol exerts its analgesic effects through micro opioid receptor agonism and noradrenaline
reuptake inhibition in the central nervous system. Preclinical studies demonstrated that …

(–)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol
HCl) is a novel μ-opioid receptor (MOR) agonist (K i = 0.1 μM; relative efficacy compared …

… Effects induced by cebranopadol or morphine were compared with those of their respective
vehicles using the Kruskal-Wallis test followed by a nonparametric Mann-Whitney U test (…

The novel centrally acting analgesic tapentadol [(−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
hydrochloride] combines two mechanisms of action, μ-opioid receptor (…

The novel analgesic tapentadol combines μ-opioid receptor agonism and noradrenaline
reuptake inhibition in a single molecule and shows potent analgesia in various rodent models …

The effects of 5-hydroxytryptamine (5-HT) on force of contraction (F C ), action potential (AP)
and calcium current (I Ca ) were studied in human right atrial and left ventricular heart …

The effects of drugs that inhibit human ether-a-go-go-related gene (HERG) related cardiac
potassium channels on the variability of QT duration as a sign of repolarisation instability …

… The area under the current trace equals the amount of charge (Q) needed for the voltage
change (U) of the membrane. CM was calculated according to CM = QU-1. CM of atrial cells …

The mechanism of drug-induced inhibition of the transient outward current, I to , has been
investigated in rat ventricular myocytes using the whole cell patch clamp technique. I to was …

… In the human ventricle, however, neither a positive inotropic effect nor an increase in Ica
was observed in response to 5-HT (Jahnel et a. 1992a). Therefore, a therapeutic benefit of …