Aging involves progressive impairments in the functional reserve of multiple organs, which
might also affect drug metabolism and pharmacokinetics. In addition, the elderly population …

Although the liver plays the major role in drug metabolism [eg by oxidative cytochrome
P450 (CYP)-dependent phase I and conjugation or phase II reactions], drug metabolising …

Aim Comparative potency of proton-pump inhibitors (PPIs) is an important clinical issue. Most
available trials have compared the different PPIs at one or a few selected specific dosages, …

This study investigates the separate effects of age and hepatocellular liver disease on the
disposition and elimination of diazepam (Valium) in man. The drug was given either by rapid …

Dietary constituents (eg, in grapefruit juice; NaCl) and phytochemicals (eg, St. John's wort)
are important agents modifying drug metabolism and transport and thereby contribute to …

Telomeres are supposed to play a role in cellular aging and might contribute to the genetic
background of human aging and longevity. During the past few years telomere length has …

… Table 1 Pharmacokinetic properties of proton pump inhibitors (according to Klotz [6]) …
Table 2 Influence of CYP2C19 genotype on intragastric pH (according to Klotz [3]) …

… Klotz U: Plasma protein binding of benzodiazepines, in Rietbrock N, Woodcock G, editors:
Methods in Clinical pharmacologyProgress in drug protein binding. Braunschweig, 1981, …

Introduction The proportion of the elderly is constantly increasing and by the year 2025 20%
of the population will be above 65 years of age. With advanced age, subjects will develop …

… [87] Walter-Sack, I.; Klotz, U. Influence of diet and nutritional status on drug metabolism.
Clin… [88] Klotz, U. Effect of aging on the pharmacokinetics of gastrointestinal drugs. In: Pilotti A, …