… endothelial subcellular organelles involved in BBB transcytosis have recently been identified
using electron microscopy and gold conjugates of the OX26 monoclonal antibody [U. Bickel…

… Samii A, Bickel U, Stroth U, Pardridge WM. Blood-brain barrier transport of neuropeptides: …
Engkvist O, Wrede P, Rester U. Prediction of CNS activity of compound libraries using …

Neuropeptides act as neuronal messengers in the brain, influencing many neurobehavioral
functions 1. Their experimental and therapeutic use in humans has been hampered because…

Low-molecular-weight polyethylenimine (LMW-PEI) was synthesized by the acid-catalyzed,
ring-opening polymerization of aziridine and compared with commercially available high-…

Drug targeting through the brain capillary endothelium, which forms the blood-brain barrier (BBB)
in vivo, may be achieved with peptidomimetic monoclonal antibodies that target …

… ACTH was assayed according to Bickel et al. (17). Antibody was obtained from the IgG …
Bickel U, Born J, Fehm HL, Distler M, Voigt KH. The behaviorally active peptide ACTH 4-10: …

… correction for trichloroacetic acid precipitability and intravascular content, the volume of
distribution (VD) of 125I-bioVIPa-avidinOX26 in brain postvascular supernatant was 32 ± 7 ,u/g …

Purpose. To study the relationship between structure of poly(ethylene imine-co-ethylene
glycol), PEI-PEG, copolymers and physicochemical properties as well as in vivo behavior of …

… Arterial blood samples were drawn after nine different time points from 20 s to 120 min, and
the sample volume (30 μl) was replaced immediately with physiologic saline containing 10 U/…

The hypothesis that P‐glycoprotein plays a functional role at the brain capillary endothelium,
which makes up the blood‐brain barrier in vivo, is based largely on immunocytochemical …