A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion

RJ Gumina, T Mizumura, N Beier, P Schelling… - … of Pharmacology and …, 1998 - ASPET
Administration of inhibitors of the Na + /H + exchanger (NHE) have been shown to produce
cardioprotective effects in a number of animal models of ischemia-reperfusion injury; however…

Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil …

T Mizumura, K Nithipatikom, GJ Gross - Circulation, 1995 - Am Heart Assoc
Background The primary goal of the present study was to determine whether the infarct size–reducing
effect of preconditioning is associated with an increase in adenosine release from …

PD 81,723, an Allosteric Enhancer of the A1 Adenosine Receptor, Lowers the Threshold for Ischemic Preconditioning in Dogs

T Mizumura, JA Auchampach, J Linden… - Circulation …, 1996 - Am Heart Assoc
PD 81,723 (PD) acts allosterically to increase agonist binding to A 1 adenosine receptors and
to enhance functional A 1 receptor–mediated responses in the heart and other tissues. To …

Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog

T Mizumura, K Nithipatikom… - Cardiovascular research, 1995 - academic.oup.com
Objective: The major aim of this study was to determine if nicorandil, a potassium channel
opener nitrate, produces a reduction in myocardial infarct size at a non-hypotensive dose in …

Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs

T Mizumura, K Nithipatikom… - Cardiovascular research, 1996 - academic.oup.com
Objectives: We wished to determine whether the cardioprotective effect of nicorandil to
reduce infarct size is blocked by glibenclamide, a selective K ATP channel antagonist, or …

KATP channels and memory of ischemic preconditioning in dogs: synergism between adenosine and KATP channels

Z Yao, T Mizumura, DA Mei… - American Journal of …, 1997 - journals.physiology.org
Results from numerous studies have shown that there is an important link between
adenosine A1 receptors and ATP-sensitive potassium (KATP) channels in mediating the …

Antiischemic effects of nicorandil during coronary angioplasty in humans

S Saito, T Mizumura, T Takayama, J Honye… - … drugs and therapy, 1995 - Springer
The present study was undertaken on 10 patients with angina undergoing percutaneous
transluminal coronary angioplasty. The angioplasty procedure consisted of two successive 30-…

Clinical utility of negative contrast intravascular ultrasound to evaluate plaque morphology before and after coronary interventions

…, J Yajima, T Shimizu, M Chiku, T Mizumura… - The American journal of …, 1999 - Elsevier
Although intravascular ultrasound (IVUS) is used for evaluation of plaque volume and
lumen size as well as detection of vessel wall structures after catheter-based interventions, …

Determination of plasma adenosine by high-performance liquid chromatography with column switching and fluorometric detection

K Nithipatikom, T Mizumura, GJ Gross - Analytical biochemistry, 1994 - Elsevier
A new method for the rapid determination of plasma adenosine concentrations was developed
by using high-performance liquid chromatography with a column switching technique and …

Intravascular Ultrasound Imaging in Human Peripheral and Coronary Arteries in Vivo: ADVANCES IN IMAGING TECHNIQUES FOR DIAGNOSIS OF …

…, T KAMATA, M TSUJI, T MIZUMURA… - Japanese Circulation …, 1992 - jstage.jst.go.jp
To detemine the feasibility of intravascular ultrasound imaging in vivo, a miniaturized high
frequency transducer catheter was introduced into human peripheral (n= 10) and coronary (n= …