Immunoglobulin G (IgG) binds specific antigens, and IgG‐antigen complexes primarily activate
immune cells and the complement system. These immune reactions are known to affect …

Our experiments were conducted to determine whether substance P (SP) would elicit an itch
sensation mediated by mast cells in mice. An intradermal injection of SP (10–135 μg site −1 …

Oxaliplatin is a chemotherapy drug and induces peripheral neuropathy which is aggravated
by exposure to cold, the mechanism of which is unclear. In the present study, we …

The pruritogenic potency of tryptase and its involvement in anti-pruritic effect of intravenous
nafamostat mesilate (NFM) were studied in mice. An intradermal injection of tryptase (0.05–1 …

Using models of serum deprivation and 1-methyl-4-phenylpyridinium (MPP + ), we investigated
the mechanism by which thioredoxin (Trx) exerts its antiapoptotic protection in human …

Preconditioning adaptation induced by transient ischemia can increase brain tolerance to
oxidative stress, but the underlying neuroprotective mechanisms are not fully understood. …

Intradermal injection of substance P elicits an itch sensation in human subjects and an itch-associated
response in mice. The substance P-induced itch-associated response in mice is …

The itch-associated responses induced by intradermal injection of leukotriene B 4 and
prostaglandin E 2 were studied in mice. Leukotriene B 4 (0.001–1 nmol/site) elicited scratching of …

Human subjects infected with herpes or varicella-zoster viruses complain of pain, such as
allodynia, in or near the region with vesicles. However, the mechanisms of the pain are unclear…

MATERIALS AND METHODS Animals Male C57BL/6 mice (Japan SLC, Ltd., Shizuoka, Japan),
6 weeks of age at the start of experiments, were used. They were housed 4—6 per cage …