Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD + -dependent
histone/protein deacetylase, promotes cell survival under oxidative stress when it is expressed …

Recently we found that the level of anti-infarct tolerance afforded by ischemic preconditioning
(IPC) and erythropoietin (EPO) infusion was closely correlated with the level of Ser9-…

To explore mechanisms by which SGLT 2 inhibitors protect diabetic hearts from heart failure,
we examined the effect of empagliflozin (Empa) on the ultrastructure of cardiomyocytes in …

OBJECTIVE Alteration in endoplasmic reticulum (ER) stress in diabetic hearts and its effect
on cytoprotective signaling are unclear. Here, we examine the hypothesis that ER stress in …

Keratinocyte growth factor (KGF, FGF-7) is a potent mitogen for epithelial cells. We instilled
recombinant human KGF to determine the effects of KGF on alveolar epithelial cells. Left …

Background Acute inflammatory reactions cause neuronal damage in cerebral ischemia-reperfusion.
Urinary trypsin inhibitor (UTI), a serine protease inhibitor, is cytoprotective against …

Acid aspiration is a serious complication of anesthesia and other forms of unconsciousness
that can result in the adult respiratory distress syndrome (ARDS), which continues to have a …

The mechanism by which SGLT2 inhibitors reduce cardiac events in diabetic patients remains
unclear. Here, we examined the effects of an SGLT2 inhibitor on the acute survival rate …

Origin of myofibroblasts in infarcted myocardium was examined by using rats in which bone
marrow of green fluorescent protein (GFP)-transgenic mice had been transplanted. GFP was …

Glycogen synthase kinase-3β (GSK-3β) is a major positive regulator of the mitochondrial
permeability transition pore (mPTP), a principle trigger of cell death, under the condition of …