Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors

T Manabe, Y Noda, T Mamiya, H Katagiri, T Houtani… - Nature, 1998 - nature.com
The peptide nociceptin (also named orphanin FQ) acts in the brain to produce various
pharmacological effects, including hyperalgesia and hypolocomotion 1 , 2 . The nociceptin …

Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

T Manabe, P Renner, RA Nicoll - Nature, 1992 - nature.com
of miniature synaptic currents Page 1 ARTICLES Postsynaptic contribution to long-term
potentiation revealed by the analysis of miniature synaptic currents Toshiya Manabe, Pius …

Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2

M Yokoi, K Kobayashi, T Manabe, T Takahashi… - Science, 1996 - science.org
Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic
elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 …

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

K Tanaka, K Watase, T Manabe, K Yamada… - Science, 1997 - science.org
Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are
maintained by transporters that actively remove glutamate from the extracellular space. …

Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus

T Manabe, DJ Wyllie, DJ Perkel… - Journal of …, 1993 - journals.physiology.org
1. Whole-cell patch-clamp recordings of excitatory postsynaptic currents (EPSCs) were
made from guinea pig hippocampal CA1 pyramidal cells. The sensitivity of paired pulse …

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

K Sakimura, T Kutsuwada, I Ito, T Manabe… - Nature, 1995 - nature.com
THE NMDA (TV-methyl-D-aspartate) receptor channel is important for synaptic plasticity,
which is thought to underlie learning, memory and development 1, 2 . The NMDA receptor …

[PDF][PDF] Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor ε2 subunit mutant mice

T Kutsuwada, K Sakimura, T Manabe, C Takayama… - Neuron, 1996 - cell.com
Multiple ε subunits are major determinants of the NMDA receptor channel diversity. Based
on their functional properties in vitro and distributions, we have proposed that the ε1 and ε2 …

[HTML][HTML] Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRε2 (NR2B) subunit of the N-methyl-D-aspartate receptor

…, H Umemori, K Semba, M Mishina, T Manabe… - Journal of Biological …, 2001 - ASBMB
The N-methyl-d-aspartate (NMDA) receptors play critical roles in synaptic plasticity, neuronal
development, and excitotoxicity. Tyrosine phosphorylation of NMDA receptors by Src-family …

Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre‐recipient layer) of the mouse hippocampal CA3 subfield

…, M Fukaya, K Sakimura, T Manabe… - European Journal of …, 1998 - Wiley Online Library
Hippocampal synapses express two distinct forms of the long‐term potentiation (LTP), ie
NMDA receptor‐dependent and ‐independent LTPs. To understand its molecular‐anatomical …

Release of adenosine by activation of NMDA receptors in the hippocampus

OJ Manzoni, T Manabe, RA Nicoll - Science, 1994 - science.org
Adenosine is present in the mammalian brain in large amounts and has potent effects on
neuronal activity, but its role in neural signaling is poorly understood. The glutamate receptor …