The secretion of bilirubin conjugates from hepatocytes into bile represents a decisive step in
the prevention of hyperbilirubinemia. The bilirubin conjugates, monoglucuronosyl bilirubin (…

Bilirubin is taken up from blood into hepatocytes by sinosuidal membrane transporters and
then excreted into bile through the bile canalicular membrane mainly as bilirubin …

Background & Aims: Multispecific organic anion–transporting polypeptides (Oatps) are involved
in the transcellular movement of amphipathic compounds in many tissues including the …

Background: Despite advances in endoscopic treatment methods for upper GI hemorrhage,
hemostasis is often difficult to achieve. This study evaluated the usefulness of endoscopic …

Regulation of bilirubin glucuronide transporters during hyperbilirubinemia in hepatic and
extrahepatic tissues is not completely clear. In the present study, we evaluated the regulation of …

The innate immunity to viral infections induces a potent antiviral response mediated by
interferons (IFN). Although IFN‐γ is detected during the acute stages of illness in the upper …

Background and Aim: Hepatic excessive iron may play a role in the pathogenesis of non‐alcoholic
steatohepatitis (NASH). Nrf2 is a master regulator of antioxidative responses. …

Recently, we reported that 4‐hydroxyderricin, one of the major chalcones in Angelica keiskei
extract (ethyl acetate extract from the yellow liquid of stems), exerted hypotensive and lipid …

Osthol, a coumarin compound, was isolated from the dried fruits of Cnidium monnieri (Umbelliferae)
and the effect of dietary osthol on hypertension and lipid metabolism was examined …

In this study, we evaluate the effect of diosgenin, ethinyl estradiol and these co-administration
on changes of lipoprotein metabolism and expression of hepatic genes those are …