[HTML][HTML] cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in …

…, M Brom, J Kartenbeck, H Spring, T Horie… - Journal of Biological …, 1996 - ASBMB
ATP-dependent transport of glutathione and glucuronate conjugates from hepatocytes into
bile is mediated by a distinct member of the ATP-binding cassette superfamily. We have …

Inflammation-based prognostic score is a novel predictor of postoperative outcome in patients with colorectal cancer

M Ishizuka, H Nagata, K Takagi, T Horie… - Annals of …, 2007 - journals.lww.com
Objective: To investigate the significance of preoperative Glasgow prognostic score (GPS)
for postoperative prognostication of patients with colorectal cancer. Background: Recent …

Distribution of glucose-6-phosphate dehydrogenase mutations in Southeast Asia

K Iwai, A Hirono, H Matsuoka, F Kawamoto, T Horie… - Human genetics, 2001 - Springer
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a heterogeneous enzyme
abnormality with high frequency in tropical areas. We performed population screening and …

Identification of cytochrome P450 isoforms involved in citalopramN-demethylation by human liver microsomes

…, T Yagi, N Shimada, T Taniguchi, T Horie… - … of Pharmacology and …, 1997 - ASPET
Studies to assess the enzyme kinetic behavior and to identify the cytochrome P450 (CYP)
isoform(s) involved in the major metabolic pathway (N-demethylation) for citalopram (CIT), a …

Expression of human cytochromes P450 in chimeric mice with humanized liver

…, C Tateno, M Kataoka, Y Soeno, T Horie… - Drug metabolism and …, 2004 - ASPET
Recently, a chimeric mouse line in which the liver could be replaced by more than 80% with
human hepatocytes was established in Japan. Because the chimeric mouse produces …

Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver

…, Y Tayama, H Ohshita, C Tateno, T Horie… - Drug Metabolism and …, 2012 - ASPET
Accurate prediction of pharmacokinetics (PK) parameters in humans from animal data is
difficult for various reasons, including species differences. However, chimeric mice with …

Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

…, K Sugihara, Y Kotake, H Ohshita, C Tateno, T Horie… - Xenobiotica, 2015 - Taylor & Francis
We used chimeric mice (PXB miceŽ), which were repopulated with human hepatocytes, to
evaluate their predictabilities of human pharmacokinetics. 2. The relationships of total …

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP …

…, W Obuchi, Y Uchida, J Kamiie, T Horie… - Drug Metabolism and …, 2014 - ASPET
Chimeric mice with humanized liver (PXB mice) have been generated by transplantation of
urokinase-type plasminogen activator/severe combined immunodeficiency mice with human …

Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes

…, N Uramaru, H Ohshita, C Tateno, T Horie… - Drug Metabolism and …, 2012 - ASPET
Prediction of human drug metabolism is important for drug development. Recently, the number
of new drug candidates metabolized by not only cytochrome P450 (P450) but also non-…

In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver

…, M Nakajima, C Tateno, Y Soeno, T Horie… - Drug metabolism and …, 2005 - ASPET
The induction and inhibition of human cytochrome P450 (P450) enzymes are clinically
responsible for drug interactions. Although the induction of P450s is investigated using human …