Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299

…, ZQD Xu, T Hökfelt, TD Wolinsky… - Proceedings of the …, 2005 - National Acad Sciences
The neuropeptide galanin mediates its effects through the receptor subtypes Gal 1 , Gal 2 ,
and Gal 3 and has been implicated in anxiety- and depression-related behaviors. …

Chronic food restriction and weight loss produce opioid facilitation of perifornical hypothalamic self-stimulation

KD Carr, TD Wolinsky - Brain research, 1993 - Elsevier
Electrical stimulation frequency thresholds for lateral hypothalamic (LH) self-stimulation were
monitored throughout a 3 week period of food restriction and a subsequent 3 week period …

The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4, 5-dihydro [1] benzothiepino [5, 4-d] thiazol-2-yl) amino] cyclohexyl] methyl] …

MW Walker, TD Wolinsky, V Jubian… - … of Pharmacology and …, 2009 - ASPET
Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y 1 , Y 2 ,
Y 4 , Y 5 , and y 6 ). The Y 5 receptor is well known for its role in appetite. Based on …

The effects of stressful stimuli and hypothalamic–pituitary–adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP …

DG Smith, LG Hegde, TD Wolinsky, S Miller… - Behavioural brain …, 2009 - Elsevier
Melanin-concentrating hormone (MCH) is an orexigenic and dipsogenic neuropeptide that
has been reported to mediate acute behavioral and neuroendocrine stress-related responses …

Chronic food restriction alters μ and κ opioid receptor binding in the parabrachial nucleus of the rat: a quantitative autoradiographic study

TD Wolinsky, KD Carr, JM Hiller, EJ Simon - Brain research, 1996 - Elsevier
Using quantitative autoradiography, it was previously observed that chronic food restriction
alters μ and κ receptor binding in several regions of the rat forebrain. The present …

Effects of chronic food restriction on mu and kappa opioid binding in rat forebrain: a quantitative autoradiographic study

TD Wolinsky, KD Carr, JM Hiller, EJ Simon - Brain research, 1994 - Elsevier
It was previously observed that chronic food restriction lowers the threshold for lateral
hypothalamic self-stimulation in a manner that is reversible by μ- and κ-selective opioid antagonists…

Positive modulation of δ-subunit containing GABAA receptors in mouse neurons

…, Z Dósa, K Boddum, MM Holm, TD Wolinsky… - …, 2012 - Elsevier
δ-subunit containing extrasynaptic GABA A receptors are potential targets for modifying
neuronal activity in a range of brain disorders. With the aim of gaining more insight in synaptic …

Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 1. The Discovery of Arylacetamides as Viable …

…, C Forray, B Li, LG Hegde, TD Wolinsky… - Journal of medicinal …, 2007 - ACS Publications
Melanin-concentrating hormone (MCH) is involved in the regulation of feeding, water balance,
energy metabolism, general arousal and attention state, memory, cognitive functions, and …

Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder

…, V Jubian, G Chandrasena, TD Wolinsky… - Bioorganic & medicinal …, 2011 - Elsevier
The structure–activity relationship of a series of tricyclic-sulfonamide compounds 11–32
culminating in the discovery of N-[trans-4-(4,5-dihydro-3,6-dithia-1-aza-benzo[e]azulen-2-…

Diabetes alters μ and κ opioid binding in rat brain regions: comparison with effects of food restriction

TD Wolinsky, GC Abrahamsen, KD Carr - Brain research, 1996 - Elsevier
Diabetic rats display changes in opioid pharmacology and brain regional levels of opioid
peptides and prodynorphin mRNA. Previous investigations of opioid receptor binding, carried …