Role of an ATP-sensitive potassium channel opener, YM934, in mitochondrial energy production in ischemic/reperfused heart

…, M Koshimizu, T Ando, T Morinaka, T Yogo… - … of Pharmacology and …, 1999 - ASPET
We examined a possible mechanism of action of an ATP-sensitive potassium (K ATP ) channel
opener, YM934, for the improvement of energy metabolism in hearts subjected to 35-min …

Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application

Y Hirozane, M Toyofuku, T Yogo, Y Tanaka… - Bioorganic & Medicinal …, 2019 - Elsevier
Selectivity profiling of compounds is important for kinase drug discovery. To this end, we
aimed to develop a broad-range protein kinase assay by synthesizing a novel staurosporine-…

Adjustment of creatinine clearance for carboplatin dosing in Calvert's formula and clinical efficacy for lung cancer

…, T Abe, Y Horio, Y Goto, N Ozawa, N Yogo… - Cancer …, 2023 - Wiley Online Library
Background The Cockcroft–Gault formula is commonly used as a substitute for glomerular
filtration rate (GFR) in Calvert's formula for carboplatin dosing, where adjusting serum …

Material dependence of energy spectra of fast electrons generated by use of high contrast laser

…, T Yabuuchi, KA Tanaka, M Nishiuchi, A Yogo… - Reza Kenkyu, 2013 - osti.gov
We studied the material dependence of electron acceleration with ultra-intense laser light at
an intensity of 5x10{sup 19} W/cm{sup 2}. Recent particle simulations have shown that the …

Small-scale panel comprising diverse gene family targets to evaluate compound promiscuity

…, M Yoshikawa, T Katoh, H Hara, T Yogo… - Chemical Research …, 2019 - ACS Publications
Despite the recent advances in the life sciences and the remarkable investment in drug
discovery research, the success rate of small-molecule drug development remains low. Safety is …

A high energy component of the intense laser-accelerated proton beams detected by stacked CR-39

…, A Hattori, H Sakaki, Y Fukuda, A Yogo… - Radiation …, 2013 - Elsevier
A precise measurement has been made utilizing a stacked CR-39 detectors unit for laser-accelerated
high intensity protons. The proton beams are derived from a thin polyimide target …

[HTML][HTML] Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

Y Sakakibara, S Hashimoto, Y Nakaoka… - Nature …, 2015 - nature.com
The frequency of chromosome segregation errors during meiosis I (MI) in oocytes increases
with age. The two-hit model suggests that errors are caused by the combination of a first hit …

Meikin is a conserved regulator of meiosis-I-specific kinetochore function

J Kim, K Ishiguro, A Nambu, B Akiyoshi, S Yokobayashi… - Nature, 2015 - nature.com
The kinetochore is the crucial apparatus regulating chromosome segregation in mitosis and
meiosis. Particularly in meiosis I, unlike in mitosis, sister kinetochores are captured by …

Author Correction: Meikin is a conserved regulator of meiosis-I-specific kinetochore function

J Kim, K Ishiguro, A Nambu, B Akiyoshi, S Yokobayashi… - Nature, 2018 - nature.com
Fig. 2| This is the corrected panel and the incorrect published panel from Fig. 3a of the original
Article. WT and Meikin−/− oocytes at early prometaphase I (2 h post GVBD) stained for …

Parallel fluorescent probe synthesis based on the large-scale preparation of BODIPY FL propionic acid

…, S Suzuki, R Koyama, N Negoro, T Yogo - Bioorganic & medicinal …, 2017 - Elsevier
We describe a methodology for quick development of fluorescent probes with the desired
potency for the target of interest by using a method of parallel synthesis, termed as Parallel …