Assessment of the first and second generation antihistamines brain penetration and role of P-glycoprotein
T Obradovic, GG Dobson, T Shingaki, T Kungu… - Pharmaceutical …, 2007 - Springer
Purpose The sedating effect of first generation H 1 -antihistamines has been associated with
their ability to penetrate the blood-brain barrier (BBB) and lack of efflux by P-glycoprotein (…
their ability to penetrate the blood-brain barrier (BBB) and lack of efflux by P-glycoprotein (…
Transnasal delivery of methotrexate to brain tumors in rats: a new strategy for brain tumor chemotherapy
T Shingaki, D Inoue, T Furubayashi… - Molecular …, 2010 - ACS Publications
Brain tumors are one of the most lethal and difficult to treat. Their treatment is limited by the
inadequate delivery of antitumor drugs to the tumor. In order to overcome this limitation, the …
inadequate delivery of antitumor drugs to the tumor. In order to overcome this limitation, the …
Visualization and quantitative assessment of the brain distribution of insulin through nose-to-brain delivery based on the cell-penetrating peptide noncovalent strategy
N Kamei, T Shingaki, Y Kanayama… - Molecular …, 2016 - ACS Publications
Our recent work suggested that intranasal coadministration with the cell-penetrating peptide
(CPP) penetratin increased the brain distribution of the peptide drug insulin. The present …
(CPP) penetratin increased the brain distribution of the peptide drug insulin. The present …
Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C] dehydropravastatin in rats
T Shingaki, T Takashima, R Ijuin, X Zhang… - … of Pharmacology and …, 2013 - ASPET
… Tomotaka Shingaki, Tadayuki Takashima, Ryosuke Ijuin, Xuan Zhang, Tomohiro Onoue,
Yumiko … Wrote or contributed to the writing of the manuscript: Shingaki, Takashima, Cui, Wada, …
Yumiko … Wrote or contributed to the writing of the manuscript: Shingaki, Takashima, Cui, Wada, …
Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [11C]Metformin in Mouse
T Shingaki, WE Hume, T Takashima, Y Katayama… - Pharmaceutical …, 2015 - Springer
Purpose To evaluate the function of multidrug and toxin extrusion proteins (MATEs) using
11 C-labeled metformin ([ 11 C]metformin) by positron emission tomography (PET). Methods …
11 C-labeled metformin ([ 11 C]metformin) by positron emission tomography (PET). Methods …
Dynamic analysis of fluid distribution in the gastrointestinal tract in rats: positron emission tomography imaging after oral administration of nonabsorbable marker,[18F] …
T Takashima, T Shingaki, Y Katayama… - Molecular …, 2013 - ACS Publications
To develop potent drugs for oral use, information on their pharmacokinetic (PK) properties
after oral administration is of great importance. We have recently reported the utility of positron …
after oral administration is of great importance. We have recently reported the utility of positron …
The synthesis and biodistribution of [11C] metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 …
WE Hume, T Shingaki, T Takashima… - Bioorganic & medicinal …, 2013 - Elsevier
In order to develop a new positron emission tomography (PET) probe to study hepatobiliary
transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1), 11 C-…
transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1), 11 C-…
The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid)
T Shingaki, IJ Hidalgo, T Furubayashi… - International journal of …, 2009 - Elsevier
The purpose of the research is to evaluate the effect of acetazolamide (AZA), an inhibitor of
the secretion of cerebrospinal fluid (CSF), on the direct drug transport from the nasal cavity to …
the secretion of cerebrospinal fluid (CSF), on the direct drug transport from the nasal cavity to …
Nasal delivery of P-gp substrates to the brain through the nose–brain pathway
T Shingaki, IJ Hidalgo, T Furubayashi… - Drug metabolism and …, 2011 - jstage.jst.go.jp
The objective of this study was to evaluate in rats the potential utility of the nasal route to
enhance central nervous system (CNS) delivery of drugs recognized by P-glycoprotein (P-gp). …
enhance central nervous system (CNS) delivery of drugs recognized by P-glycoprotein (P-gp). …
In vitro evaluation of the ciliary beat frequency of the rat nasal epithelium using a high-speed digital imaging system
…, K Ogawara, T Kimura, K Higaki, T Shingaki… - Biological and …, 2013 - jstage.jst.go.jp
Mucociliary clearance (MC) is an important factor in determining nasal drug absorption and
the ciliary beat of ciliated epithelial cells of the nasal mucosa is the driving force of MC. …
the ciliary beat of ciliated epithelial cells of the nasal mucosa is the driving force of MC. …