The interaction between leukocyte function-associated antigen-1 (LFA-1) and intracellular
adhesion molecule-1 (ICAM-1) has been implicated in inflammatory and immune diseases. …

The interaction between leukocyte function-associated antigen-1 (LFA-1), a member of the
β 2 -integrin family of adhesion molecules, and intracellular adhesion molecule ICAM-1 (cd54…

Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases,
bind to ET A and ET B receptors to initiate their effects. Based on the same core structure, …

We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma
cruzi ( T. cruzi ), the causative agent of Chagas disease, and the results of structure–activity …

There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of
the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective …

Glucocorticoids amplify endogenous glucose production in type 2 diabetes by increasing
hepatic glucose output. Systemic glucocorticoid blockade lowers glucose levels in type 2 …

Dipeptidyl peptidase IV (DPP4) inhibitors are emerging as a new class of therapeutic agents
for the treatment of type 2 diabetes. They exert their beneficial effects by increasing the …

We have discovered a novel class of endothelin (ET) receptor antagonists through pharmacophore
analysis of the existing non-peptide ET antagonists. On the basis of this analysis, we …

A series of (5-substituted pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidine (C5-Pro-Pro) analogues
was discovered as dipeptidyl peptidase IV (DPPIV) inhibitors as a potential treatment of …

Hepatic blockade of glucocorticoid receptors (GR) suppresses glucose production and thus
decreases circulating glucose levels, but systemic glucocorticoid antagonism can produce …