1 The mechanisms responsible for sensing hypoxia and initiating hypoxic pulmonary
vasoconstriction (HPV) are unclear. We therefore examined the roles of the mitochondrial electron …

We have examined the effects of Y‐27632, a specific inhibitor of Rho‐activated kinases (ROCK
I and ROCK II) upon sustained hypoxic pulmonary vasoconstriction (HPV) in both rat …

The vascular endothelium synthesises, metabolises or converts a multitude of vasoactive
mediators, and plays a vital role in the regulation of pulmonary vascular resistance. Its role in …

The pulmonary circulation differs from the systemic in several important aspects, the most
important being that pulmonary arteries constrict to moderate physiological (∼20–60 mmHg P …

Novel approaches are needed to reduce the high rates of childhood obesity in the developed
world. While multifactorial in cause, a major factor is an increasingly sedentary lifestyle of …

Equine laminitis is a crippling condition associated with a variety of systemic diseases.
Although it is apparent that the prodromal stages of laminitis involve microvascular dysfunction, …

The effect of induction of capacitative Ca 2+ entry (CCE) upon tone in small (id 200–500 μm)
intrapulmonary (IPA), mesenteric (MA), renal (RA), femoral (FA), and coronary arteries (CA) …

The main aim of this study was to determine the effects of endothelium removal on tension
and intracellular Ca 2+ ([Ca 2+ ] i ) during hypoxic pulmonary vasoconstriction (HPV) in rat …

The precise mechanisms underlying hypoxic pulmonary vasoconstriction (HPV) are still
elusive. The recent discovery of K+ channels that are depressed by hypoxia in pulmonary …

Objective: Sustained hypoxic pulmonary vasoconstriction is dependent upon the presence of
an intact endothelium, strongly suggesting that an endothelium-derived constrictor factor is …