[HTML][HTML] Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants

…, I Rajan, Q Yang, E Cullinan, TH Lanthorn - PloS one, 2008 - journals.plos.org
The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and central
nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting enzymes…

Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord

AH Ganong, TH Lanthorn, CW Cotman - Brain research, 1983 - Elsevier
Kynurenic acid, a tryptophan metabolite, inhibits excitatory synaptic transmission in the rat
hippocampal slice and the isolated immature rat spinal cord, but does not affect membrane …

Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention

…, J Mower, MF Rafferty, RL Herting, TH Lanthorn - European journal of …, 1994 - Elsevier
The memory-enhancing potential of D-cycloserine (cycloserine) a partial agonist at the
glycine recognition site on the NMDA receptor, was evaluated in mice using a thirst-motivated …

d-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed inXenopus oocytes

…, MP Baganoff, CL Deppeler, TH Lanthorn - Brain research, 1990 - Elsevier
In theXenopus oocyte preparation, d-cycloserine (DCS) had the profile of a partial agonist at
the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the …

Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain

…, K O'Malley, J Lippy, A Nouraldeen, TH Lanthorn… - … of Pharmacology and …, 2016 - ASPET
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute
and persistent pain behavior assays. One of the lines from this screen, which contained a …

Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor

JF Flood, JE Morley, TH Lanthorn - European journal of pharmacology, 1992 - Elsevier
Glycine has been shown to modulate N-methyl-D-aspartate (NMDA) subclass of acidic
amino acid receptors which have been implicated in learning and memory. We report that d-…

D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats

MG Baxter, TH Lanthorn, KM Frick, S Golski… - Neurobiology of …, 1994 - Elsevier
D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance
cognition. The present experiment examines the behavioral effects of D-cycloserine on …

[HTML][HTML] Diacylglycerol lipase α knockout mice demonstrate metabolic and behavioral phenotypes similar to those of cannabinoid receptor 1 knockout mice

…, D Doree, KV Savelieva, TH Lanthorn… - Frontiers in …, 2015 - frontiersin.org
After creating >4,650 knockouts (KOs) of independent mouse genes, we screened them by
high-throughput phenotyping and found that cannabinoid receptor 1 (Cnr1) KO mice had the …

Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes

DA Gurley, TH Lanthorn - Neuroscience letters, 1998 - Elsevier
The 5-HT 3 receptor (5-HT 3 R) is part of a superfamily of ligand-gated ion channels which
includes nicotinic acetylcholine receptors (nAChR). cRNA derived from the long isoform …

Experimental ischemia induces a persistent depolarization blocked by decreased calcium and NMDA antagonists

RK Rader, TH Lanthorn - Neuroscience letters, 1989 - Elsevier
Early physiological events induced by hypoxia plus low d-glucose were investigated by
intracellular recording in the rat hippocampal slice. A rapid intracellular depolarization …